{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Manandhar S"],"funding":["Heart Foundation of New Zealand Small Project Grant","University of Otago Research Grant","Christchurch Heart Institute Trust","Health Research Council Programme Grant"],"pagination":["8639"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9368963"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(15)"],"pubmed_abstract":["Hydrogen sulfide (H<sub>2</sub>S) and substance P (SP) are known from animal models and in vitro studies as proinflammatory mediators. In this study, peripheral blood concentrations of H<sub>2</sub>S and SP were measured in patients with <i>Escherichia coli</i> or <i>Klebsiella pneumoniae</i> bacteraemia. Fifty patients were recruited from general wards at Christchurch Hospital, during 2020-2021. Samples from age- and sex-matched healthy subjects previously recruited as controls for studies of cardiovascular disease were used as controls. The concentrations of H<sub>2</sub>S were higher than controls on day 0, day 1, and day 2, and SP was higher than controls on all 4 days. The concentrations of H<sub>2</sub>S were highest on day 0, whereas SP concentrations were higher on day 2 than other"],"journal":["International journal of molecular sciences"],"pubmed_title":["Hydrogen Sulfide and Substance P Levels in Patients with <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i> Bacteraemia."],"pmcid":["PMC9368963"],"funding_grant_id":["1838","11/170"],"pubmed_authors":["Sinha P","Bhatia M","Cameron V","Pilbrow A","Harrington M","Chambers ST","Richards AM","Manandhar S","Scott-Thomas A"],"additional_accession":[]},"is_claimable":false,"name":"Hydrogen Sulfide and Substance P Levels in Patients with <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i> Bacteraemia.","description":"Hydrogen sulfide (H<sub>2</sub>S) and substance P (SP) are known from animal models and in vitro studies as proinflammatory mediators. In this study, peripheral blood concentrations of H<sub>2</sub>S and SP were measured in patients with <i>Escherichia coli</i> or <i>Klebsiella pneumoniae</i> bacteraemia. Fifty patients were recruited from general wards at Christchurch Hospital, during 2020-2021. Samples from age- and sex-matched healthy subjects previously recruited as controls for studies of cardiovascular disease were used as controls. The concentrations of H<sub>2</sub>S were higher than controls on day 0, day 1, and day 2, and SP was higher than controls on all 4 days. The concentrations of H<sub>2</sub>S were highest on day 0, whereas SP concentrations were higher on day 2 than other","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Aug","modification":"2025-04-19T22:56:33.822Z","creation":"2025-02-19T03:31:52.775Z"},"accession":"S-EPMC9368963","cross_references":{"pubmed":["35955767"],"doi":["10.3390/ijms23158639"]}}