biostudies-literatureKotha RRUnited States Department of AgricultureOffice of Dietary Supplements, NIH4883https://www.ebi.ac.uk/biostudies/studies/S-EPMC9369953biostudies-literatureUnknown27(15)In this study, we evaluated the extractability of three curcuminoids (curcumin, demethoxycurcumin, and bisdemethoxycurcumin) from turmeric powder in several solvents using high-performance liquid chromatography (HPLC) with the diode-array detection method. These solvents include water, milk (homogenized, 2% reduced fat, low fat, fat free, soy, almond, coconut, and milkadamia), and aqueous ethanols (0%, 4%, 10%, 20%, 30%, 40%, 50%, and 100%). Ambient water was able to extract only 0.55 mg/g of curcuminoids, whereas warm water extracted more than four-fold higher amounts (2.42 mg/g). Almond, coconut, and milkadamia milk were able to extract only small amounts of curcuminoids at ambient temperatures (0.01-0.07 mg/g). The extractability of curcuminoids in these milk types did not improve, evenMolecules (Basel, Switzerland)Extractability of Curcuminoids Is Enhanced with Milk and Aqueous-Alcohol Mixtures.PMC93699531235-52000-066-00D19006-001-00000Kotha RRTareq FSLuthria DLfalseExtractability of Curcuminoids Is Enhanced with Milk and Aqueous-Alcohol Mixtures.In this study, we evaluated the extractability of three curcuminoids (curcumin, demethoxycurcumin, and bisdemethoxycurcumin) from turmeric powder in several solvents using high-performance liquid chromatography (HPLC) with the diode-array detection method. These solvents include water, milk (homogenized, 2% reduced fat, low fat, fat free, soy, almond, coconut, and milkadamia), and aqueous ethanols (0%, 4%, 10%, 20%, 30%, 40%, 50%, and 100%). Ambient water was able to extract only 0.55 mg/g of curcuminoids, whereas warm water extracted more than four-fold higher amounts (2.42 mg/g). Almond, coconut, and milkadamia milk were able to extract only small amounts of curcuminoids at ambient temperatures (0.01-0.07 mg/g). The extractability of curcuminoids in these milk types did not improve, even2022-01-01T00:00:00Z2022 Jul2025-04-05T08:56:52.514Z2024-11-06T09:52:03.246ZS-EPMC93699533595683410.3390/molecules27154883