biostudies-literatureYue QNatural Science Foundation of Hebei ProvinceBasic Research Program of Science and Technology in the Education Department of Hebei ProvinceNational Natural Science Foundation of China4922https://www.ebi.ac.uk/biostudies/studies/S-EPMC9370360biostudies-literatureUnknown27(15)As a critical molecule in the onset and sustainment of inflammatory response, the receptor for advanced glycation end products (RAGE) has a variety of ligands, such as advanced glycation end products (AGEs), S100/calcium granule protein, and high-mobility group protein 1 (HMGB1). Recently, an increasing number studies have shown that RAGE ligand binding can initiate the intracellular signal cascade, affect intracellular signal transduction, stimulate the release of cytokines, and play a vital role in the occurrence and development of immune-related diseases, such as systemic lupus erythematosus, rheumatoid arthritis, and Alzheimer's disease. In addition, other RAGE signaling pathways can play crucial roles in life activities, such as inflammation, apoptosis, autophagy, and endoplasmic retiMolecules (Basel, Switzerland)Receptor for Advanced Glycation End Products (RAGE): A Pivotal Hub in Immune Diseases.PMC9370360No. 82003404H2019209576JQN2019012Liu ZLi JYang LYue QZhang LSong YfalseReceptor for Advanced Glycation End Products (RAGE): A Pivotal Hub in Immune Diseases.As a critical molecule in the onset and sustainment of inflammatory response, the receptor for advanced glycation end products (RAGE) has a variety of ligands, such as advanced glycation end products (AGEs), S100/calcium granule protein, and high-mobility group protein 1 (HMGB1). Recently, an increasing number studies have shown that RAGE ligand binding can initiate the intracellular signal cascade, affect intracellular signal transduction, stimulate the release of cytokines, and play a vital role in the occurrence and development of immune-related diseases, such as systemic lupus erythematosus, rheumatoid arthritis, and Alzheimer's disease. In addition, other RAGE signaling pathways can play crucial roles in life activities, such as inflammation, apoptosis, autophagy, and endoplasmic reti2022-01-01T00:00:00Z2022 Aug2025-04-04T08:01:33.761Z2025-04-04T08:01:33.761ZS-EPMC93703603595687510.3390/molecules27154922