{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["101(32)"],"submitter":["Han B"],"pubmed_abstract":["Abnormal development of the atrioventricular ring can lead to the formation of a bypass pathway and the occurrence of Wolff-Parkinson-White (WPW) syndrome. The genetic mechanism underlying the sporadic form of WPW syndrome remains unclear. Existing evidence suggests that both T-box transcription factor 3 (TBX3) and T-box transcription factor 2 (TBX2) genes participate in regulating annulus fibrosus formation and atrioventricular canal development. Thus, we aimed to examine whether single-nucleotide polymorphisms (SNPs) in the TBX3 and TBX2 genes confer susceptibility to WPW syndrome in a Han Chinese Population. We applied a SNaPshot SNP assay to analyze 5 selected tagSNPs of TBX3 and TBX2 in 230 patients with sporadic WPW syndrome and 231 sex- and age-matched controls. Haplotype analysis w"],"journal":["Medicine"],"pagination":["e30046"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9371508"],"repository":["biostudies-literature"],"pubmed_title":["Association of T-box gene polymorphisms with the risk of Wolff-Parkinson-White syndrome in a Han Chinese population."],"pmcid":["PMC9371508"],"pubmed_authors":["Han B","Zhang J","Zhang Z","Lan Q","Bai M","Wang Y","Zhao J","Jin J","Meng X"],"additional_accession":[]},"is_claimable":false,"name":"Association of T-box gene polymorphisms with the risk of Wolff-Parkinson-White syndrome in a Han Chinese population.","description":"Abnormal development of the atrioventricular ring can lead to the formation of a bypass pathway and the occurrence of Wolff-Parkinson-White (WPW) syndrome. The genetic mechanism underlying the sporadic form of WPW syndrome remains unclear. Existing evidence suggests that both T-box transcription factor 3 (TBX3) and T-box transcription factor 2 (TBX2) genes participate in regulating annulus fibrosus formation and atrioventricular canal development. Thus, we aimed to examine whether single-nucleotide polymorphisms (SNPs) in the TBX3 and TBX2 genes confer susceptibility to WPW syndrome in a Han Chinese Population. We applied a SNaPshot SNP assay to analyze 5 selected tagSNPs of TBX3 and TBX2 in 230 patients with sporadic WPW syndrome and 231 sex- and age-matched controls. Haplotype analysis w","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Aug","modification":"2025-04-22T21:38:23.82Z","creation":"2024-11-12T21:24:09.07Z"},"accession":"S-EPMC9371508","cross_references":{"pubmed":["35960099"],"doi":["10.1097/MD.0000000000030046"]}}