biostudies-literatureUnknown101(32)Han BAbnormal development of the atrioventricular ring can lead to the formation of a bypass pathway and the occurrence of Wolff-Parkinson-White (WPW) syndrome. The genetic mechanism underlying the sporadic form of WPW syndrome remains unclear. Existing evidence suggests that both T-box transcription factor 3 (TBX3) and T-box transcription factor 2 (TBX2) genes participate in regulating annulus fibrosus formation and atrioventricular canal development. Thus, we aimed to examine whether single-nucleotide polymorphisms (SNPs) in the TBX3 and TBX2 genes confer susceptibility to WPW syndrome in a Han Chinese Population. We applied a SNaPshot SNP assay to analyze 5 selected tagSNPs of TBX3 and TBX2 in 230 patients with sporadic WPW syndrome and 231 sex- and age-matched controls. Haplotype analysis wMedicinee30046https://www.ebi.ac.uk/biostudies/studies/S-EPMC9371508biostudies-literatureAssociation of T-box gene polymorphisms with the risk of Wolff-Parkinson-White syndrome in a Han Chinese population.PMC9371508Han BZhang JZhang ZLan QBai MWang YZhao JJin JMeng XfalseAssociation of T-box gene polymorphisms with the risk of Wolff-Parkinson-White syndrome in a Han Chinese population.Abnormal development of the atrioventricular ring can lead to the formation of a bypass pathway and the occurrence of Wolff-Parkinson-White (WPW) syndrome. The genetic mechanism underlying the sporadic form of WPW syndrome remains unclear. Existing evidence suggests that both T-box transcription factor 3 (TBX3) and T-box transcription factor 2 (TBX2) genes participate in regulating annulus fibrosus formation and atrioventricular canal development. Thus, we aimed to examine whether single-nucleotide polymorphisms (SNPs) in the TBX3 and TBX2 genes confer susceptibility to WPW syndrome in a Han Chinese Population. We applied a SNaPshot SNP assay to analyze 5 selected tagSNPs of TBX3 and TBX2 in 230 patients with sporadic WPW syndrome and 231 sex- and age-matched controls. Haplotype analysis w2022-01-01T00:00:00Z2022 Aug2025-04-22T21:38:23.82Z2024-11-12T21:24:09.07ZS-EPMC93715083596009910.1097/MD.0000000000030046