{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhai J"],"funding":["National University of Singapore","Ministry of Education - Singapore"],"pagination":["e2203883119"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9371748"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["119(32)"],"pubmed_abstract":["L-type Ca<sub>V</sub>1.3 calcium channels are expressed on the dendrites and soma of neurons, and there is a paucity of information about its role in hippocampal plasticity. Here, by genetic targeting to ablate Ca<sub>V</sub>1.3 RNA editing, we demonstrate that unedited Ca<sub>V</sub>1.3<sup>ΔECS</sup> mice exhibited improved learning and enhanced long-term memory, supporting a functional role of RNA editing in behavior. Significantly, the editing paradox that functional recoding of Ca<sub>V</sub>1.3 RNA editing sites slows Ca<sup>2+</sup>-dependent inactivation to increase Ca<sup>2+</sup> influx but reduces channel open probability to decrease Ca<sup>2+</sup> influx was resolved. Mechanistically, using hippocampal slice recordings, we provide evidence that unedited Ca<sub>V</sub>1.3 chann"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Loss of Ca<sub>V</sub>1.3 RNA editing enhances mouse hippocampal plasticity, learning, and memory."],"pmcid":["PMC9371748"],"funding_grant_id":["R185000271720","SS)","MOE2019-T2-2-024 (TWS)","NUHSRO/2018/075/NUSMed-FoS/01(TWS"],"pubmed_authors":["Wong RX","Sajikumar S","Liang MC","Yeow SQZ","Krishna-K K","Yu WP","Huang H","Zhai J","Soong TW","Koh JH","Navakkode S"],"additional_accession":[]},"is_claimable":false,"name":"Loss of Ca<sub>V</sub>1.3 RNA editing enhances mouse hippocampal plasticity, learning, and memory.","description":"L-type Ca<sub>V</sub>1.3 calcium channels are expressed on the dendrites and soma of neurons, and there is a paucity of information about its role in hippocampal plasticity. Here, by genetic targeting to ablate Ca<sub>V</sub>1.3 RNA editing, we demonstrate that unedited Ca<sub>V</sub>1.3<sup>ΔECS</sup> mice exhibited improved learning and enhanced long-term memory, supporting a functional role of RNA editing in behavior. Significantly, the editing paradox that functional recoding of Ca<sub>V</sub>1.3 RNA editing sites slows Ca<sup>2+</sup>-dependent inactivation to increase Ca<sup>2+</sup> influx but reduces channel open probability to decrease Ca<sup>2+</sup> influx was resolved. Mechanistically, using hippocampal slice recordings, we provide evidence that unedited Ca<sub>V</sub>1.3 chann","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Aug","modification":"2025-04-19T17:58:21.309Z","creation":"2025-04-19T17:58:21.309Z"},"accession":"S-EPMC9371748","cross_references":{"pubmed":["35914168"],"doi":["10.1073/pnas.2203883119"]}}