{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["20(1)"],"submitter":["Welzel T"],"funding":["Universitätsklinikum Tübingen"],"pubmed_abstract":["<h4>Background</h4>Biological treatment and treat-to-target approaches guide the achievement of inactive disease and clinical remission in Autoinflammatory Diseases (AID). However, there is limited evidence addressing optimal tapering strategies and/or discontinuation of biological treatment in AID. This study evaluates available evidence of tapering biological treatment and explores key factors for successful tapering.<h4>Methods</h4>A systematic literature search was conducted in Embase, MEDLINE, Cochrane Database of Systematic Reviews and Cochrane Central Register of Controlled Trials using the OVID platform (1990-08/2020). Bibliographic search of relevant reviews was also performed. Studies/case series (n ≥ 5) in AID patients aged ≤ 18 years with biological treatment providing informat"],"journal":["Pediatric rheumatology online journal"],"pagination":["67"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9375310"],"repository":["biostudies-literature"],"pubmed_title":["Tapering of biological treatment in autoinflammatory diseases: a scoping review."],"pmcid":["PMC9375310"],"pubmed_authors":["Kuemmerle-Deschner JB","Pfister M","Welzel T","Benseler SM","Oefelein L","Twilt M"],"additional_accession":[]},"is_claimable":false,"name":"Tapering of biological treatment in autoinflammatory diseases: a scoping review.","description":"<h4>Background</h4>Biological treatment and treat-to-target approaches guide the achievement of inactive disease and clinical remission in Autoinflammatory Diseases (AID). However, there is limited evidence addressing optimal tapering strategies and/or discontinuation of biological treatment in AID. This study evaluates available evidence of tapering biological treatment and explores key factors for successful tapering.<h4>Methods</h4>A systematic literature search was conducted in Embase, MEDLINE, Cochrane Database of Systematic Reviews and Cochrane Central Register of Controlled Trials using the OVID platform (1990-08/2020). Bibliographic search of relevant reviews was also performed. Studies/case series (n ≥ 5) in AID patients aged ≤ 18 years with biological treatment providing informat","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Aug","modification":"2025-04-04T10:29:35.807Z","creation":"2025-04-04T10:29:35.807Z"},"accession":"S-EPMC9375310","cross_references":{"pubmed":["35964053"],"doi":["10.1186/s12969-022-00725-3"]}}