biostudies-literatureUnknown20(1)Welzel TUniversitätsklinikum Tübingen<h4>Background</h4>Biological treatment and treat-to-target approaches guide the achievement of inactive disease and clinical remission in Autoinflammatory Diseases (AID). However, there is limited evidence addressing optimal tapering strategies and/or discontinuation of biological treatment in AID. This study evaluates available evidence of tapering biological treatment and explores key factors for successful tapering.<h4>Methods</h4>A systematic literature search was conducted in Embase, MEDLINE, Cochrane Database of Systematic Reviews and Cochrane Central Register of Controlled Trials using the OVID platform (1990-08/2020). Bibliographic search of relevant reviews was also performed. Studies/case series (n ≥ 5) in AID patients aged ≤ 18 years with biological treatment providing informatPediatric rheumatology online journal67https://www.ebi.ac.uk/biostudies/studies/S-EPMC9375310biostudies-literatureTapering of biological treatment in autoinflammatory diseases: a scoping review.PMC9375310Kuemmerle-Deschner JBPfister MWelzel TBenseler SMOefelein LTwilt MfalseTapering of biological treatment in autoinflammatory diseases: a scoping review.<h4>Background</h4>Biological treatment and treat-to-target approaches guide the achievement of inactive disease and clinical remission in Autoinflammatory Diseases (AID). However, there is limited evidence addressing optimal tapering strategies and/or discontinuation of biological treatment in AID. This study evaluates available evidence of tapering biological treatment and explores key factors for successful tapering.<h4>Methods</h4>A systematic literature search was conducted in Embase, MEDLINE, Cochrane Database of Systematic Reviews and Cochrane Central Register of Controlled Trials using the OVID platform (1990-08/2020). Bibliographic search of relevant reviews was also performed. Studies/case series (n ≥ 5) in AID patients aged ≤ 18 years with biological treatment providing informat2022-01-01T00:00:00Z2022 Aug2025-04-04T10:29:35.807Z2025-04-04T10:29:35.807ZS-EPMC93753103596405310.1186/s12969-022-00725-3