{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Baßler K"],"funding":["NIAID NIH HHS","NIMH NIH HHS","NCI NIH HHS"],"pagination":["917232"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9377018"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13"],"pubmed_abstract":["Despite its high prevalence, the cellular and molecular mechanisms of chronic obstructive pulmonary disease (COPD) are far from being understood. Here, we determine disease-related changes in cellular and molecular compositions within the alveolar space and peripheral blood of a cohort of COPD patients and controls. Myeloid cells were the largest cellular compartment in the alveolar space with invading monocytes and proliferating macrophages elevated in COPD. Modeling cell-to-cell communication, signaling pathway usage, and transcription factor binding predicts TGF-β1 to be a major upstream regulator of transcriptional changes in alveolar macrophages of COPD patients. Functionally, macrophages in COPD showed reduced antigen presentation capacity, accumulation of cholesteryl ester, reduced "],"journal":["Frontiers in immunology"],"pubmed_title":["Alveolar macrophages in early stage COPD show functional deviations with properties of impaired immune activation."],"pmcid":["PMC9377018"],"funding_grant_id":["U54 CA217377","U24 AI118672","U19 MH114821"],"pubmed_authors":["Dudkin E","Skowasch D","Becker M","Kohler M","Ferreira HJ","Reiz B","Knoll R","Holsten L","Theis FJ","Thomas D","Baum P","Schultze JL","Kraut M","Baßler K","Fujii W","Handler K","Schreiber T","Kaltheuner IH","Thiele C","Geyer M","Reusch N","Wagner A","Gunther P","Hughes TK","Beyer M","Hasenauer J","Dickten H","Luecken MD","Horne A","De Domenico E","Theis H","Hinkley E","Kapellos TS","Aschenbrenner AC","Wadsworth MH","Osei-Sarpong C","Schulte-Schrepping J","Pizarro C","Kroger C","Wohnhaas CT","Yosef N","Bonaguro L","Shalek AK","Ulas T","Warnat-Herresthal S","Feißt A","Baumgartner F"],"additional_accession":[]},"is_claimable":false,"name":"Alveolar macrophages in early stage COPD show functional deviations with properties of impaired immune activation.","description":"Despite its high prevalence, the cellular and molecular mechanisms of chronic obstructive pulmonary disease (COPD) are far from being understood. Here, we determine disease-related changes in cellular and molecular compositions within the alveolar space and peripheral blood of a cohort of COPD patients and controls. Myeloid cells were the largest cellular compartment in the alveolar space with invading monocytes and proliferating macrophages elevated in COPD. Modeling cell-to-cell communication, signaling pathway usage, and transcription factor binding predicts TGF-β1 to be a major upstream regulator of transcriptional changes in alveolar macrophages of COPD patients. Functionally, macrophages in COPD showed reduced antigen presentation capacity, accumulation of cholesteryl ester, reduced ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-04-08T11:08:07.122Z","creation":"2025-02-19T04:38:25.695Z"},"accession":"S-EPMC9377018","cross_references":{"pubmed":["35979364"],"doi":["10.3389/fimmu.2022.917232"]}}