{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(7)"],"submitter":["Burns J"],"pubmed_abstract":["<h4>Background</h4>Assessing the real-world effectiveness of COVID-19 vaccines and understanding the incidence and severity of SARS-CoV-2 illness in children are essential to inform policy and guide health care professionals in advising parents and caregivers of children who test positive for SARS-CoV-2.<h4>Objective</h4>This report describes the objectives and methods for conducting the Pediatric Research Observing Trends and Exposures in COVID-19 Timelines (PROTECT) study. PROTECT is a longitudinal prospective pediatric cohort study designed to estimate SARS-CoV-2 incidence and COVID-19 vaccine effectiveness (VE) against infection among children aged 6 months to 17 years, as well as differences in SARS-CoV-2 infection and vaccine response between children and adolescents.<h4>Methods</h4>"],"journal":["JMIR research protocols"],"pagination":["e37929"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9377426"],"repository":["biostudies-literature"],"pubmed_title":["Pediatric Research Observing Trends and Exposures in COVID-19 Timelines (PROTECT): Protocol for a Multisite Longitudinal Cohort Study."],"pmcid":["PMC9377426"],"pubmed_authors":["Yoon SK","Hegmann KT","Wesley MG","Lowe AA","Gwynn L","Thompson MG","Olsho LE","Odame-Bamfo L","Rentz Hunt D","Hollister J","Gerald JK","Tyner HL","Khan SM","Ochoa JS","Burgess JL","Herring MK","Edwards LJ","Odean MJ","LeClair LB","Ellingson K","Jacoby KB","Yoo YM","Meece JK","Fowlkes AL","Pubillones FA","Thiese MS","Madhivanan P","Grant L","Schaefer Solle N","Beitel S","Naleway AL","Mak J","Gaglani M","Rai RP","Lopez J","Rivers P","Krupp K","McLeland-Wieser H","Lamberte JM","Berry MC","Gerald LB","Sokol BE","Caban-Martinez AJ","Burns J","Jovel KS","Ferraris M","Kuntz JL","Lutrick K","Phillips AL","Mathenge C"],"additional_accession":[]},"is_claimable":false,"name":"Pediatric Research Observing Trends and Exposures in COVID-19 Timelines (PROTECT): Protocol for a Multisite Longitudinal Cohort Study.","description":"<h4>Background</h4>Assessing the real-world effectiveness of COVID-19 vaccines and understanding the incidence and severity of SARS-CoV-2 illness in children are essential to inform policy and guide health care professionals in advising parents and caregivers of children who test positive for SARS-CoV-2.<h4>Objective</h4>This report describes the objectives and methods for conducting the Pediatric Research Observing Trends and Exposures in COVID-19 Timelines (PROTECT) study. PROTECT is a longitudinal prospective pediatric cohort study designed to estimate SARS-CoV-2 incidence and COVID-19 vaccine effectiveness (VE) against infection among children aged 6 months to 17 years, as well as differences in SARS-CoV-2 infection and vaccine response between children and adolescents.<h4>Methods</h4>","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jul","modification":"2025-04-05T10:35:49.214Z","creation":"2025-04-05T10:35:49.214Z"},"accession":"S-EPMC9377426","cross_references":{"pubmed":["35635842"],"doi":["10.2196/37929"]}}