biostudies-literatureUnknown11(7)Burns J<h4>Background</h4>Assessing the real-world effectiveness of COVID-19 vaccines and understanding the incidence and severity of SARS-CoV-2 illness in children are essential to inform policy and guide health care professionals in advising parents and caregivers of children who test positive for SARS-CoV-2.<h4>Objective</h4>This report describes the objectives and methods for conducting the Pediatric Research Observing Trends and Exposures in COVID-19 Timelines (PROTECT) study. PROTECT is a longitudinal prospective pediatric cohort study designed to estimate SARS-CoV-2 incidence and COVID-19 vaccine effectiveness (VE) against infection among children aged 6 months to 17 years, as well as differences in SARS-CoV-2 infection and vaccine response between children and adolescents.<h4>Methods</h4>JMIR research protocolse37929https://www.ebi.ac.uk/biostudies/studies/S-EPMC9377426biostudies-literaturePediatric Research Observing Trends and Exposures in COVID-19 Timelines (PROTECT): Protocol for a Multisite Longitudinal Cohort Study.PMC9377426Yoon SKHegmann KTWesley MGLowe AAGwynn LThompson MGOlsho LEOdame-Bamfo LRentz Hunt DHollister JGerald JKTyner HLKhan SMOchoa JSBurgess JLHerring MKEdwards LJOdean MJLeClair LBEllingson KJacoby KBYoo YMMeece JKFowlkes ALPubillones FAThiese MSMadhivanan PGrant LSchaefer Solle NBeitel SNaleway ALMak JGaglani MRai RPLopez JRivers PKrupp KMcLeland-Wieser HLamberte JMBerry MCGerald LBSokol BECaban-Martinez AJBurns JJovel KSFerraris MKuntz JLLutrick KPhillips ALMathenge CfalsePediatric Research Observing Trends and Exposures in COVID-19 Timelines (PROTECT): Protocol for a Multisite Longitudinal Cohort Study.<h4>Background</h4>Assessing the real-world effectiveness of COVID-19 vaccines and understanding the incidence and severity of SARS-CoV-2 illness in children are essential to inform policy and guide health care professionals in advising parents and caregivers of children who test positive for SARS-CoV-2.<h4>Objective</h4>This report describes the objectives and methods for conducting the Pediatric Research Observing Trends and Exposures in COVID-19 Timelines (PROTECT) study. PROTECT is a longitudinal prospective pediatric cohort study designed to estimate SARS-CoV-2 incidence and COVID-19 vaccine effectiveness (VE) against infection among children aged 6 months to 17 years, as well as differences in SARS-CoV-2 infection and vaccine response between children and adolescents.<h4>Methods</h4>2022-01-01T00:00:00Z2022 Jul2025-04-05T10:35:49.214Z2025-04-05T10:35:49.214ZS-EPMC93774263563584210.2196/37929