biostudies-literatureBell RMSingapore Ministry of Health’s National Medical Research CouncilBritish Heart FoundationRosetrees TrustDeutsche ForschungsgemeinschaftNational Institute for Health Research (NIHR)National Research Foundation SingaporePGCDuke-NUS Signature Research Programme39https://www.ebi.ac.uk/biostudies/studies/S-EPMC9377667biostudies-literatureUnknown117(1)The Hatter Cardiovascular Institute biennial workshop, originally scheduled for April 2020 but postponed for 2 years due to the Covid pandemic, was organised to debate and discuss the future of Remote Ischaemic Conditioning (RIC). This evolved from the large multicentre CONDI-2-ERIC-PPCI outcome study which demonstrated no additional benefit when using RIC in the setting of ST-elevation myocardial infarction (STEMI). The workshop discussed how conditioning has led to a significant and fundamental understanding of the mechanisms preventing cell death following ischaemia and reperfusion, and the key target cyto-protective pathways recruited by protective interventions, such as RIC. However, the obvious need to translate this protection to the clinical setting has not materialised largely dueBasic research in cardiologyRemote ischaemic conditioning: defining critical criteria for success-report from the 11th Hatter Cardiovascular Workshop.PMC9377667FS/18/80/33937M565NMRC CG21APR1006-MOH-STaR21jun-0003CRC 1116 B8FS/CRTF/21/24251PG/21/107982018-094025-B-I00MCIN/AEI/10.13039/501100011033NIHR128240PG/19/51/34493PG/18/10/33550NMRC/CG21APRC006Bell RMHausenloy DJIbanez BNtsekhe MEngland TJYellon DMCunningham JWalker JMLecour SBeikoghli Kalkhoran SDavidson SMBasalay MGhosh AKKleinbongard PGiesz SLukhna KOvize MHeusch GVilahur GCarr RDGolforoush PBotker HEGourine AVSalama ADfalseRemote ischaemic conditioning: defining critical criteria for success-report from the 11th Hatter Cardiovascular Workshop.The Hatter Cardiovascular Institute biennial workshop, originally scheduled for April 2020 but postponed for 2 years due to the Covid pandemic, was organised to debate and discuss the future of Remote Ischaemic Conditioning (RIC). This evolved from the large multicentre CONDI-2-ERIC-PPCI outcome study which demonstrated no additional benefit when using RIC in the setting of ST-elevation myocardial infarction (STEMI). The workshop discussed how conditioning has led to a significant and fundamental understanding of the mechanisms preventing cell death following ischaemia and reperfusion, and the key target cyto-protective pathways recruited by protective interventions, such as RIC. However, the obvious need to translate this protection to the clinical setting has not materialised largely due2022-01-01T00:00:00Z2022 Aug2025-05-29T14:36:46.506Z2024-12-03T16:23:05.382ZS-EPMC93776673597095410.1007/s00395-022-00947-2