biostudies-literatureYin XCenter for Pediatric Genomics Award and CCRF Endowed Scholar Award of Cincinnati Children’s HospitalYoung ProgramMinistry of Education, Culture, Sports, Sciences and Technology of the Japanese Government and AMEDNRFMinistry of Science &amp; ICT of the Republic of KoreaBasic Science Research ProgramNational Natural Science Foundation of ChinaNational ProgramNIHRIKEN Junior Research Associate ProgramProgram for New Century Excellent Talents in University of Ministry of Education of ChinaMinistry of EducationScience Foundation of Ministry of Education of ChinaKey Basic Research Project of ChinaCenter for Genome Science, Korea National Institute of Health, Republic of KoreaJapan Agency for Medical Research and DevelopmentScience Fund for Creative Research GroupsGeneral ProgramBio &amp; Medical Technology Development Program of the National Research FoundationMinistry of Science, ICT and Future PlanningYoung Scholar of Provincial Natural Science Foundation of AnhuiCenters for Disease Control and Prevention, Republic of KoreaExchange Program1273-1280https://www.ebi.ac.uk/biostudies/studies/S-EPMC9380500biostudies-literatureUnknown81(9)<h4>Objective</h4>Genome-wide association studies (GWAS) have identified >100 risk loci for systemic lupus erythematosus (SLE), but the disease genes at most loci remain unclear, hampering translation of these genetic discoveries. We aimed to prioritise genes underlying the 110 SLE loci that were identified in the latest East Asian GWAS meta-analysis.<h4>Methods</h4>We built gene expression predictive models in blood B cells, CD4⁺ and CD8⁺ T cells, monocytes, natural killer cells and peripheral blood cells of 105 Japanese individuals. We performed a transcriptome-wide association study (TWAS) using data from the latest genome-wide association meta-analysis of 208 370 East Asians and searched for candidate genes using TWAS and three data-driven computational approachesAnnals of the rheumatic diseasesBiological insights into systemic lupus erythematosus through an immune cell-specific transcriptome-wide association study.PMC9380500818725168187252731630021AI148276213018A818813404241808085J08AI024717BX001834KBN-2018-0313000-303181803117NCET-12-0600HG17211181421001AR0705492015R1C1A1A02036527DK107502AI130830815730334845-301818300192017R1E1A1A010763882014CB541901Mukai MSugano NHuang HShen NKoido MShen CTerao CMatsuo KKwon YCIshigaki KKawaguchi YLau YLWang MKang YMWen LOtomo NJapanese Research Committee on Idiopathic Osteonecrosis of the Femoral HeadMatsuda KYamamoto KSheng YTakahashi DZheng XNakamura JLi CAtsumi TFei WLee YKYamamoto TWang YFLi KPark DJKim BJYoon KPark YBTakeuchi TBang SYSakamoto YLi WSuzuki AYang WIkegawa SHwang MYKuroda TYang SAmano KSumida TShimizu MDing HNiiro HLiu LZhu ZCai MKim KChung WTOhmura KLee HSPark YKochi YHa ESuh CHTang YShin JMTada YYin XKarino KShim SCLeng RXYamaji KBae SCChoe JYKim THMiyamoto TOkada YMiyamura TCui YSuetsugu HZhang XYe DLee SSJo SAhn GYMotomura GfalseBiological insights into systemic lupus erythematosus through an immune cell-specific transcriptome-wide association study.<h4>Objective</h4>Genome-wide association studies (GWAS) have identified >100 risk loci for systemic lupus erythematosus (SLE), but the disease genes at most loci remain unclear, hampering translation of these genetic discoveries. We aimed to prioritise genes underlying the 110 SLE loci that were identified in the latest East Asian GWAS meta-analysis.<h4>Methods</h4>We built gene expression predictive models in blood B cells, CD4⁺ and CD8⁺ T cells, monocytes, natural killer cells and peripheral blood cells of 105 Japanese individuals. We performed a transcriptome-wide association study (TWAS) using data from the latest genome-wide association meta-analysis of 208 370 East Asians and searched for candidate genes using TWAS and three data-driven computational approaches2022-01-01T00:00:00Z2022 Aug2026-06-12T10:00:11.412Z2024-11-10T02:25:04.251ZS-EPMC93805003560997610.1136/annrheumdis-2022-222345