biostudies-literatureUnknown14Yang M<i>FOXP2</i>, cognitive deficits, and schizophrenia are associated with neurodegenerative pathophyisiology. Mounting evidence suggests that body mass index (BMI) and <i>FOXP2</i> may contribute to cognitive deficits in schizophrenia. However, the sex difference in the contribution of <i>FOXP2</i> and BMI, as well as their potential interaction with cognitive deficits in schizophrenia, have not been investigated. A total of 867 schizophrenia patients and 402 controls were recruited. Cognitive function was assessed using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). The polymorphism rs10447760 of the <i>FOXP2</i> gene was genotyped. Male schizophrenia patients had superior language performance compared to female patients (<i>F</i> = 17.83; <i>p</i> <sub>BonfFrontiers in aging neuroscience920352https://www.ebi.ac.uk/biostudies/studies/S-EPMC9381810biostudies-literatureSexual dimorphism in the relationship between <i>Forkhead-Box P2</i> and BMI with cognitive deficits in schizophrenia.PMC9381810Li ZCui YYang MZhang XXiu MForster MTXue MLang XfalseSexual dimorphism in the relationship between <i>Forkhead-Box P2</i> and BMI with cognitive deficits in schizophrenia.<i>FOXP2</i>, cognitive deficits, and schizophrenia are associated with neurodegenerative pathophyisiology. Mounting evidence suggests that body mass index (BMI) and <i>FOXP2</i> may contribute to cognitive deficits in schizophrenia. However, the sex difference in the contribution of <i>FOXP2</i> and BMI, as well as their potential interaction with cognitive deficits in schizophrenia, have not been investigated. A total of 867 schizophrenia patients and 402 controls were recruited. Cognitive function was assessed using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). The polymorphism rs10447760 of the <i>FOXP2</i> gene was genotyped. Male schizophrenia patients had superior language performance compared to female patients (<i>F</i> = 17.83; <i>p</i> <sub>Bonf2022-01-01T00:00:00Z20222025-04-22T21:48:06.963Z2025-02-19T01:28:08.964ZS-EPMC93818103599259410.3389/fnagi.2022.920352