biostudies-literatureUnknown328(7)Chen HS<h4>Importance</h4>Preclinical and clinical studies have suggested a neuroprotective effect of remote ischemic conditioning (RIC), which involves repeated occlusion/release cycles on bilateral upper limb arteries; however, robust evidence in patients with ischemic stroke is lacking.<h4>Objective</h4>To assess the efficacy of RIC for acute moderate ischemic stroke.<h4>Design, setting, and participants</h4>This multicenter, open-label, blinded-end point, randomized clinical trial including 1893 patients with acute moderate ischemic stroke was conducted at 55 hospitals in China from December 26, 2018, through January 19, 2021, and the date of final follow-up was April 19, 2021.<h4>Interventions</h4>Eligible patients were randomly assigned within 48 hours after symptom onset to receive treatmeJAMA627-636https://www.ebi.ac.uk/biostudies/studies/S-EPMC9382441biostudies-literatureEffect of Remote Ischemic Conditioning vs Usual Care on Neurologic Function in Patients With Acute Moderate Ischemic Stroke: The RICAMIS Randomized Clinical Trial.PMC9382441RICAMIS InvestigatorsLi XQQiu XFChen HSDeng CQWang HZhang LWang XHZhang QWang XJZhang YJWang XLSun MGeng SMMeng ZMLiu YJWan LSWang YSun JLi YSWang LQLi JChen SYWang DLGuo LYWang DQWang LYZhang HLLi LGong XHXu JYang KHLi ZWang DYFeng JChen JYJiang CHYu MMa LLi RHZhai JHYu XKZhao YShen LYZhao LHBi CWang RPLi MNFeng YFHa CXiao HBHong MChang DWYan TGBai FSBao YBai YLi JYMa YTYu HYNie CMeng CHan BCui YZhang ZHSong XHWang GCJiang HTZheng WXHan JZou RLShi JJiao ZfalseEffect of Remote Ischemic Conditioning vs Usual Care on Neurologic Function in Patients With Acute Moderate Ischemic Stroke: The RICAMIS Randomized Clinical Trial.<h4>Importance</h4>Preclinical and clinical studies have suggested a neuroprotective effect of remote ischemic conditioning (RIC), which involves repeated occlusion/release cycles on bilateral upper limb arteries; however, robust evidence in patients with ischemic stroke is lacking.<h4>Objective</h4>To assess the efficacy of RIC for acute moderate ischemic stroke.<h4>Design, setting, and participants</h4>This multicenter, open-label, blinded-end point, randomized clinical trial including 1893 patients with acute moderate ischemic stroke was conducted at 55 hospitals in China from December 26, 2018, through January 19, 2021, and the date of final follow-up was April 19, 2021.<h4>Interventions</h4>Eligible patients were randomly assigned within 48 hours after symptom onset to receive treatme2022-01-01T00:00:00Z2022 Aug2026-05-09T22:39:00.916Z2025-02-19T03:26:34.956ZS-EPMC93824413597248510.1001/jama.2022.13123