biostudies-literatureUnknown107(9)Jalleh RJ<h4>Context</h4>The relationships of gastric emptying (GE) with the glycemic response at 120 minutes, glucagon-like peptide-1 (GLP-1), and insulin secretion following a glucose load in type 2 diabetes (T2D) are uncertain.<h4>Objective</h4>We evaluated the relationship of plasma glucose, GLP-1, and insulin secretion with GE of a 75-g oral glucose load in T2D.<h4>Design</h4>Single-center, cross-sectional, post hoc analysis.<h4>Setting</h4>Institutional research center.<h4>Participants</h4>43 individuals with T2D age 65.6 ± 1.1 years, hemoglobin A1c 7.2 ± 1.0%, median duration of diabetes 5 years managed by diet and/or metformin.<h4>Intervention</h4>Participants consumed the glucose drink radiolabeled with 99mTc-phytate colloid following an overnight fast. GE (scintigraphy), plasma glucose, GThe Journal of clinical endocrinology and metabolisme3850-e3856https://www.ebi.ac.uk/biostudies/studies/S-EPMC9387705biostudies-literatureRelationships of Glucose, GLP-1, and Insulin Secretion With Gastric Emptying After a 75-g Glucose Load in Type 2 Diabetes.PMC9387705Marathe CSHorowitz MJones KLJalleh RJWu TRayner CKfalseRelationships of Glucose, GLP-1, and Insulin Secretion With Gastric Emptying After a 75-g Glucose Load in Type 2 Diabetes.<h4>Context</h4>The relationships of gastric emptying (GE) with the glycemic response at 120 minutes, glucagon-like peptide-1 (GLP-1), and insulin secretion following a glucose load in type 2 diabetes (T2D) are uncertain.<h4>Objective</h4>We evaluated the relationship of plasma glucose, GLP-1, and insulin secretion with GE of a 75-g oral glucose load in T2D.<h4>Design</h4>Single-center, cross-sectional, post hoc analysis.<h4>Setting</h4>Institutional research center.<h4>Participants</h4>43 individuals with T2D age 65.6 ± 1.1 years, hemoglobin A1c 7.2 ± 1.0%, median duration of diabetes 5 years managed by diet and/or metformin.<h4>Intervention</h4>Participants consumed the glucose drink radiolabeled with 99mTc-phytate colloid following an overnight fast. GE (scintigraphy), plasma glucose, G2022-01-01T00:00:00Z2022 Aug2025-04-05T11:27:38.529Z2025-04-05T11:27:38.529ZS-EPMC93877053560882310.1210/clinem/dgac330