{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Marcus DM"],"funding":["NEI NIH HHS","NIDDK NIH HHS"],"pagination":["946-954"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9389433"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["140(10)"],"pubmed_abstract":["<h4>Importance</h4>Ultra-widefield (UWF) imaging improves the ability to identify peripheral diabetic retinopathy (DR) lesions compared with standard imaging. Whether detection of predominantly peripheral lesions (PPLs) better predicts rates of disease worsening over time is unknown.<h4>Objective</h4>To determine whether PPLs identified on UWF imaging are associated with increased disease worsening beyond the risk associated with baseline Early Treatment Diabetic Retinopathy Study (ETDRS) Diabetic Retinopathy Severity Scale (DRSS) score.<h4>Design, setting, and participants</h4>This cohort study was a prospective, multicenter, longitudinal observational study conducted at 37 US and Canadian sites with 388 participants enrolled between February and December 2015. At baseline and annually th"],"journal":["JAMA ophthalmology"],"pubmed_title":["Association of Predominantly Peripheral Lesions on Ultra-Widefield Imaging and the Risk of Diabetic Retinopathy Worsening Over Time."],"pmcid":["PMC9389433"],"funding_grant_id":["UG1 EY014231","P30 DK036836"],"pubmed_authors":["Makkena V","James MF","Major JC","Benz MS","Bowers J","Koger-Grifaldo H","Shah CP","Johnson MA","Rhoton N","Guillory A","Sampani K","Hampton GR","Rehling SM","Ovando Y","Cadwell DM","Corak B","Peters MA","Almanza BA","Fox GM","Bailey T","Berger BB","McClain D","Cavallerano JD","Stern BA","White L","DuBose EL","Winter PA","Brent MH","Preston CM","Leder HA","Moinfar N","Castillo E","Elvena GL","Wilson DM","Walker JP","Miller A","Wiechelt L","Stockman ME","Robarge NE","Carli W","Rowland BO","Hong G","Yeager FT","Hosein K","Boisvert TF","Richter BA","Asher J","McOwen MD","McCoy T","Adamo AM","Bobbitt BJ","Cao S","Bojaj SJ","Fish RH","Lince RE","Shaheen J","Connor TB","Ortega I","Knips 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AM","Carter TM","Constantine SR","Baker CW","Barnhart CJ","Singletary PV"],"additional_accession":[]},"is_claimable":false,"name":"Association of Predominantly Peripheral Lesions on Ultra-Widefield Imaging and the Risk of Diabetic Retinopathy Worsening Over Time.","description":"<h4>Importance</h4>Ultra-widefield (UWF) imaging improves the ability to identify peripheral diabetic retinopathy (DR) lesions compared with standard imaging. Whether detection of predominantly peripheral lesions (PPLs) better predicts rates of disease worsening over time is unknown.<h4>Objective</h4>To determine whether PPLs identified on UWF imaging are associated with increased disease worsening beyond the risk associated with baseline Early Treatment Diabetic Retinopathy Study (ETDRS) Diabetic Retinopathy Severity Scale (DRSS) score.<h4>Design, setting, and participants</h4>This cohort study was a prospective, multicenter, longitudinal observational study conducted at 37 US and Canadian sites with 388 participants enrolled between February and December 2015. At baseline and annually th","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-04T20:07:10.609Z","creation":"2025-04-04T20:07:10.609Z"},"accession":"S-EPMC9389433","cross_references":{"pubmed":["35980608"],"doi":["10.1001/jamaophthalmol.2022.3131"]}}