{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Carberry CK"],"funding":["NIEHS NIH HHS"],"pagination":["107419"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9389917"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["167"],"pubmed_abstract":["<h4>Introduction</h4>Wildfires are a threat to public health world-wide that are growing in intensity and prevalence. The biological mechanisms that elicit wildfire-associated toxicity remain largely unknown. The potential involvement of cross-tissue communication via extracellular vesicles (EVs) is a new mechanism that has yet to be evaluated.<h4>Methods</h4>Female CD-1 mice were exposed to smoke condensate samples collected from the following biomass burn scenarios: flaming peat; smoldering peat; flaming red oak; and smoldering red oak, representing lab-based simulations of wildfire scenarios. Lung tissue, bronchoalveolar lavage fluid (BALF) samples, peripheral blood, and heart tissues were collected 4 and 24 h post-exposure. Exosome-enriched EVs were isolated from plasma, physically cha"],"journal":["Environment international"],"pubmed_title":["Wildfires and extracellular vesicles: Exosomal MicroRNAs as mediators of cross-tissue cardiopulmonary responses to biomass smoke."],"pmcid":["PMC9389917"],"funding_grant_id":["R21 ES031740","T32 ES007018","P30 ES010126","P42 ES031007"],"pubmed_authors":["Hartwell H","Carberry CK","Jaspers I","Ian Gilmour M","Rager JE","Payton A","Reif DM","Smith GJ","Ho Kim Y","Koval LE"],"additional_accession":[]},"is_claimable":false,"name":"Wildfires and extracellular vesicles: Exosomal MicroRNAs as mediators of cross-tissue cardiopulmonary responses to biomass smoke.","description":"<h4>Introduction</h4>Wildfires are a threat to public health world-wide that are growing in intensity and prevalence. The biological mechanisms that elicit wildfire-associated toxicity remain largely unknown. The potential involvement of cross-tissue communication via extracellular vesicles (EVs) is a new mechanism that has yet to be evaluated.<h4>Methods</h4>Female CD-1 mice were exposed to smoke condensate samples collected from the following biomass burn scenarios: flaming peat; smoldering peat; flaming red oak; and smoldering red oak, representing lab-based simulations of wildfire scenarios. Lung tissue, bronchoalveolar lavage fluid (BALF) samples, peripheral blood, and heart tissues were collected 4 and 24 h post-exposure. Exosome-enriched EVs were isolated from plasma, physically cha","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2026-05-31T16:02:38.667Z","creation":"2025-02-19T01:27:42.798Z"},"accession":"S-EPMC9389917","cross_references":{"pubmed":["35863239"],"doi":["10.1016/j.envint.2022.107419"]}}