biostudies-literatureGarfinkle RCanadian Association of General SurgeonsSociety of American Gastrointestinal and Endoscopic Surgeons3934-3943https://www.ebi.ac.uk/biostudies/studies/S-EPMC9390101biostudies-literatureUnknown37(5)<h4>Introduction</h4>The objective of this study was to evaluate the impact of preoperative bowel stimulation on the development of postoperative ileus (POI) after loop ileostomy closure.<h4>Methods</h4>This was a multicenter, randomized controlled trial (NCT025596350) including adult (≥ 18 years old) patients who underwent elective loop ileostomy closure at 7 participating hospitals. Participants were randomly assigned (1:1) using a centralized computer-generated sequence with block randomization to either preoperative bowel stimulation or no stimulation (control group). Bowel stimulation consisted of 10 outpatient sessions within the 3 weeks prior to ileostomy closure and was performed by trained Enterostomal Therapy nurses. The primary outcome was POI, defined as an intolerance to oral Surgical endoscopyBowel stimulation before loop ileostomy closure to reduce postoperative ileus: a multicenter, single-blinded, randomized controlled trial.PMC939010146924689Vasilevsky CALee LCharlebois PFaria JHameed UDemian MGarfinkle RHerd AStein BLiberman ASNisbet SSabboobeh SBoutros MRajaratnam SStotland PBowel Stimulation Research CollaborativeMorin NChadi SAJarvis JQuereshy FBhama ARDemyttenaere STataryn DFeinberg SHulme-Moir MQuintin LHayden DMSamuel LHotakorzian NGhitulescu GMoot AMoon JfalseBowel stimulation before loop ileostomy closure to reduce postoperative ileus: a multicenter, single-blinded, randomized controlled trial.<h4>Introduction</h4>The objective of this study was to evaluate the impact of preoperative bowel stimulation on the development of postoperative ileus (POI) after loop ileostomy closure.<h4>Methods</h4>This was a multicenter, randomized controlled trial (NCT025596350) including adult (≥ 18 years old) patients who underwent elective loop ileostomy closure at 7 participating hospitals. Participants were randomly assigned (1:1) using a centralized computer-generated sequence with block randomization to either preoperative bowel stimulation or no stimulation (control group). Bowel stimulation consisted of 10 outpatient sessions within the 3 weeks prior to ileostomy closure and was performed by trained Enterostomal Therapy nurses. The primary outcome was POI, defined as an intolerance to oral 2023-01-01T00:00:00Z2023 May2026-05-31T16:07:32.258Z2025-02-19T01:27:30.325ZS-EPMC93901013598452110.1007/s00464-022-09510-5