{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lehmann S"],"funding":["Erasmus Mundus Action 2","Deutsche Forschungsgemeinschaft","Georg-August-Universität Göttingen"],"pagination":["608"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9392906"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(1)"],"pubmed_abstract":["<h4>Background</h4>Functional genomics uses unbiased systematic genome-wide gene disruption or analyzes natural variations such as gene expression profiles of different tissues from multicellular organisms to link gene functions to particular phenotypes. Functional genomics approaches are of particular importance to identify large sets of genes that are specifically important for a particular biological process beyond known candidate genes, or when the process has not been studied with genetic methods before.<h4>Results</h4>Here, we present a large set of genes whose disruption interferes with the function of the odoriferous defensive stink glands of the red flour beetle Tribolium castaneum. This gene set is the result of a large-scale systematic phenotypic screen using RNA interference ap"],"journal":["BMC genomics"],"pubmed_title":["Phenotypic screen and transcriptomics approach complement each other in functional genomics of defensive stink gland physiology."],"pmcid":["PMC9392906"],"funding_grant_id":["SmartLink: South-East-West Mobility","FOR 1234, BU 1443/7-1, BU 1443/7-2, KL 656/7-1, KL 656/7-2"],"pubmed_authors":["Richter T","Li J","Ansari S","Teuscher M","Hakeemi MS","Strohlein N","Lehmann S","Atika B","Weißkopf M","Grossmann D","Bucher G","Majumdar U","Klingler M","Wimmer EA","Schmitt-Engel C","Weißbecker B"],"additional_accession":[]},"is_claimable":false,"name":"Phenotypic screen and transcriptomics approach complement each other in functional genomics of defensive stink gland physiology.","description":"<h4>Background</h4>Functional genomics uses unbiased systematic genome-wide gene disruption or analyzes natural variations such as gene expression profiles of different tissues from multicellular organisms to link gene functions to particular phenotypes. Functional genomics approaches are of particular importance to identify large sets of genes that are specifically important for a particular biological process beyond known candidate genes, or when the process has not been studied with genetic methods before.<h4>Results</h4>Here, we present a large set of genes whose disruption interferes with the function of the odoriferous defensive stink glands of the red flour beetle Tribolium castaneum. This gene set is the result of a large-scale systematic phenotypic screen using RNA interference ap","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Aug","modification":"2025-04-04T22:36:02.258Z","creation":"2024-11-15T18:45:52.356Z"},"accession":"S-EPMC9392906","cross_references":{"pubmed":["35987630"],"doi":["10.1186/s12864-022-08822-z"]}}