{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Hu Q"],"pubmed_abstract":["Copper is an essential microelement for the body and a necessary coregulator for enzymatic reactions, yet an unbalanced copper level promotes reactive oxidation and cytotoxicity, which ultimately induces cell death. Several small molecules targeting copper-induced cell death have been investigated, yet few showed promising therapeutic effects in clinical trials. In March 2022, <i>Science</i> first introduced the concept and mechanisms of cuproptosis, suggesting that copper-induced cell death targets the tricarboxylic acid (TCA) cycle <i>via</i> protein lipoylation. Does this novel form of cell death take part in tumorigenesis or tumor progression? Is cuproptosis related to clinical outcomes of diseases? Is there a cuproptosis-related panel for clinical practice in cancer treatment? Herein,"],"journal":["Frontiers in oncology"],"pagination":["922332"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9393616"],"repository":["biostudies-literature"],"pubmed_title":["Cuproptosis predicts the risk and clinical outcomes of lung adenocarcinoma."],"pmcid":["PMC9393616"],"pubmed_authors":["Wang R","Zhang Z","Xue Q","Ma H","Hu Q"],"additional_accession":[]},"is_claimable":false,"name":"Cuproptosis predicts the risk and clinical outcomes of lung adenocarcinoma.","description":"Copper is an essential microelement for the body and a necessary coregulator for enzymatic reactions, yet an unbalanced copper level promotes reactive oxidation and cytotoxicity, which ultimately induces cell death. Several small molecules targeting copper-induced cell death have been investigated, yet few showed promising therapeutic effects in clinical trials. In March 2022, <i>Science</i> first introduced the concept and mechanisms of cuproptosis, suggesting that copper-induced cell death targets the tricarboxylic acid (TCA) cycle <i>via</i> protein lipoylation. Does this novel form of cell death take part in tumorigenesis or tumor progression? Is cuproptosis related to clinical outcomes of diseases? Is there a cuproptosis-related panel for clinical practice in cancer treatment? Herein,","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-04-08T18:05:23.019Z","creation":"2025-02-19T01:28:18.881Z"},"accession":"S-EPMC9393616","cross_references":{"pubmed":["36003780"],"doi":["10.3389/fonc.2022.922332"]}}