biostudies-literatureUnknown12Hu QCopper is an essential microelement for the body and a necessary coregulator for enzymatic reactions, yet an unbalanced copper level promotes reactive oxidation and cytotoxicity, which ultimately induces cell death. Several small molecules targeting copper-induced cell death have been investigated, yet few showed promising therapeutic effects in clinical trials. In March 2022, <i>Science</i> first introduced the concept and mechanisms of cuproptosis, suggesting that copper-induced cell death targets the tricarboxylic acid (TCA) cycle <i>via</i> protein lipoylation. Does this novel form of cell death take part in tumorigenesis or tumor progression? Is cuproptosis related to clinical outcomes of diseases? Is there a cuproptosis-related panel for clinical practice in cancer treatment? Herein,Frontiers in oncology922332https://www.ebi.ac.uk/biostudies/studies/S-EPMC9393616biostudies-literatureCuproptosis predicts the risk and clinical outcomes of lung adenocarcinoma.PMC9393616Wang RZhang ZXue QMa HHu QfalseCuproptosis predicts the risk and clinical outcomes of lung adenocarcinoma.Copper is an essential microelement for the body and a necessary coregulator for enzymatic reactions, yet an unbalanced copper level promotes reactive oxidation and cytotoxicity, which ultimately induces cell death. Several small molecules targeting copper-induced cell death have been investigated, yet few showed promising therapeutic effects in clinical trials. In March 2022, <i>Science</i> first introduced the concept and mechanisms of cuproptosis, suggesting that copper-induced cell death targets the tricarboxylic acid (TCA) cycle <i>via</i> protein lipoylation. Does this novel form of cell death take part in tumorigenesis or tumor progression? Is cuproptosis related to clinical outcomes of diseases? Is there a cuproptosis-related panel for clinical practice in cancer treatment? Herein,2022-01-01T00:00:00Z20222026-04-08T18:05:23.019Z2025-02-19T01:28:18.881ZS-EPMC93936163600378010.3389/fonc.2022.922332