{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10"],"submitter":["Wang X"],"pubmed_abstract":["<b>Background</b>: Doxorubicin resistance remains a major therapeutic challenge leading to poor survival prognosis and treatment failure in breast cancer. Although doxorubicin induces massive changes in the transcriptional landscape are well known, potential diagnostic or therapeutic targets associated with the reorganization of three-dimensional (3D) chromatin architecture have not yet been systematically investigated. <b>Methods:</b> Here we performed <i>in situ</i> high-throughput chromosome conformation capture (Hi-C) on parental and doxorubicin-resistant MCF7 (MCF7-DR) human breast cancer cells, followed by integrative analysis of HiC, ATAC-seq, RNA-seq and TCGA data. <b>Results:</b> It revealed that A/B compartment switching was positively correlated to genome-wide differential gene "],"journal":["Frontiers in cell and developmental biology"],"pagination":["974750"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9393755"],"repository":["biostudies-literature"],"pubmed_title":["Reorganization of 3D chromatin architecture in doxorubicin-resistant breast cancer cells."],"pmcid":["PMC9393755"],"pubmed_authors":["Yan J","Zhang Z","Wang S","Wang X","Shen B","Wei G","Hao S","Ye Z"],"additional_accession":[]},"is_claimable":false,"name":"Reorganization of 3D chromatin architecture in doxorubicin-resistant breast cancer cells.","description":"<b>Background</b>: Doxorubicin resistance remains a major therapeutic challenge leading to poor survival prognosis and treatment failure in breast cancer. Although doxorubicin induces massive changes in the transcriptional landscape are well known, potential diagnostic or therapeutic targets associated with the reorganization of three-dimensional (3D) chromatin architecture have not yet been systematically investigated. <b>Methods:</b> Here we performed <i>in situ</i> high-throughput chromosome conformation capture (Hi-C) on parental and doxorubicin-resistant MCF7 (MCF7-DR) human breast cancer cells, followed by integrative analysis of HiC, ATAC-seq, RNA-seq and TCGA data. <b>Results:</b> It revealed that A/B compartment switching was positively correlated to genome-wide differential gene ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-05-31T16:07:22.147Z","creation":"2025-02-19T01:28:24.762Z"},"accession":"S-EPMC9393755","cross_references":{"pubmed":["36003143"],"doi":["10.3389/fcell.2022.974750"]}}