{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Abreu S"],"funding":["Agence Nationale de la Recherche"],"pagination":["1026"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9394261"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(8)"],"pubmed_abstract":["<i>Yarrowia lipolytica</i> is a promising oleaginous yeast for producing unusual lipids, such as odd-chain fatty acids (OCFA). Their diverse applications and low natural production make OCFA particularly interesting. In recent studies, inhibiting the catabolic pathway of precursor, boosting precursor pools, and optimizing substrate combination greatly improved the production of OCFA in <i>Y. lipolytica</i>. We explored the lipid readjustment of OCFA in engineered <i>Y. lipolytica</i> strains. NPLC-Corona-CAD<sup>®</sup> evidenced a time-dependent overproduction of free fatty acids, diglycerides, and phosphatidylcholine (PC) in obese LP compared to obese L. Phosphatidylethanolamine (PE) and phosphatidylinositol, largely overproduced in obese LP at 72 h compared to obese L, vanished at 216 h"],"journal":["Biomolecules"],"pubmed_title":["Lipid Readjustment in <i>Yarrowia lipolytica</i> Odd-Chain Fatty Acids Producing Strains."],"pmcid":["PMC9394261"],"funding_grant_id":["Investissements d’avenir, Poc in Labs 2020-1011"],"pubmed_authors":["Abreu S","Chaminade P","Pires de Souza C","Park YK","Nicaud JM","Vidal L"],"additional_accession":[]},"is_claimable":false,"name":"Lipid Readjustment in <i>Yarrowia lipolytica</i> Odd-Chain Fatty Acids Producing Strains.","description":"<i>Yarrowia lipolytica</i> is a promising oleaginous yeast for producing unusual lipids, such as odd-chain fatty acids (OCFA). Their diverse applications and low natural production make OCFA particularly interesting. In recent studies, inhibiting the catabolic pathway of precursor, boosting precursor pools, and optimizing substrate combination greatly improved the production of OCFA in <i>Y. lipolytica</i>. We explored the lipid readjustment of OCFA in engineered <i>Y. lipolytica</i> strains. NPLC-Corona-CAD<sup>®</sup> evidenced a time-dependent overproduction of free fatty acids, diglycerides, and phosphatidylcholine (PC) in obese LP compared to obese L. Phosphatidylethanolamine (PE) and phosphatidylinositol, largely overproduced in obese LP at 72 h compared to obese L, vanished at 216 h","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jul","modification":"2025-04-04T21:35:38.619Z","creation":"2025-04-04T21:35:38.619Z"},"accession":"S-EPMC9394261","cross_references":{"pubmed":["35892336"],"doi":["10.3390/biom12081026"]}}