{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Luo T"],"funding":["National Cancer Institute","NCI NIH HHS"],"pagination":["5241-5246"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9396732"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["144(12)"],"pubmed_abstract":["Herein we report that dimensional reduction from three-dimensional nanoscale metal-organic frameworks (nMOFs) to two-dimensional nanoscale metal-organic layers (nMOLs) increases the frequency of encounters between photosensitizers and oxygen and facilitates the diffusion of singlet oxygen from the nMOL to significantly enhance photodynamic therapy. The nMOFs and nMOLs share the same M<sub>12</sub>-oxo (M = Zr, Hf) secondary building units and 5,15-di-<i>p</i>-benzoatoporphyrin (DBP) ligands but exhibit three-dimensional and two-dimensional topologies, respectively. Molecular dynamics simulations and experimental studies revealed that the nMOLs with a monolayer morphology enhanced the generation of reactive oxygen species and exhibited over an order of magnitude higher cytotoxicity over the"],"journal":["Journal of the American Chemical Society"],"pubmed_title":["Dimensional Reduction Enhances Photodynamic Therapy of Metal-Organic Nanophotosensitizers."],"pmcid":["PMC9396732"],"funding_grant_id":["U01 CA198989","R01 CA253655","U01-CA198989","P30 CA014599","1R01CA253655"],"pubmed_authors":["Yuan E","Fan Y","Lin W","You E","Xu Z","Luo T","Mao J"],"additional_accession":[]},"is_claimable":false,"name":"Dimensional Reduction Enhances Photodynamic Therapy of Metal-Organic Nanophotosensitizers.","description":"Herein we report that dimensional reduction from three-dimensional nanoscale metal-organic frameworks (nMOFs) to two-dimensional nanoscale metal-organic layers (nMOLs) increases the frequency of encounters between photosensitizers and oxygen and facilitates the diffusion of singlet oxygen from the nMOL to significantly enhance photodynamic therapy. The nMOFs and nMOLs share the same M<sub>12</sub>-oxo (M = Zr, Hf) secondary building units and 5,15-di-<i>p</i>-benzoatoporphyrin (DBP) ligands but exhibit three-dimensional and two-dimensional topologies, respectively. Molecular dynamics simulations and experimental studies revealed that the nMOLs with a monolayer morphology enhanced the generation of reactive oxygen species and exhibited over an order of magnitude higher cytotoxicity over the","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-04T21:34:59.639Z","creation":"2025-04-04T21:34:59.639Z"},"accession":"S-EPMC9396732","cross_references":{"pubmed":["35297640"],"doi":["10.1021/jacs.2c00384"]}}