biostudies-literatureHamfjord JNorwegian Cancer Society342-351https://www.ebi.ac.uk/biostudies/studies/S-EPMC9398128biostudies-literatureUnknown31(2)<h4>Background</h4>Patients with right-sided colon cancer (RCC) and left-sided colon cancer (LCC) differ clinically and molecularly. The main objective was to investigate stage-stratified survival and recurrence of RCC and LCC across four 10-year periods.<h4>Methods</h4>Patients diagnosed from 1977 to 2016 with colon adenocarcinoma were included from the Cancer Registry of Norway. Primary tumor location (PTL) was defined as RCC if proximal and LCC if distal to the splenic flexure. Multivariable regressions were used to estimate HRs for overall survival (OS), recurrence-free survival (RFS), survival after recurrence (SAR), and excess HRs (eHR) for relative survival (RS).<h4>Results</h4>72,224 patients were eligible for analyses [55.1% (<i>n</i> = 39,769/72,224) had RCC]. In 1977 to 1986, thCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive OncologySurvival Trends of Right- and Left-Sided Colon Cancer across Four Decades: A Norwegian Population-Based Study.PMC9398128190188-2017Myklebust TAGlimelius BHamfjord JKure EHLarsen IKGuren MGGuren TKTveit KMfalseSurvival Trends of Right- and Left-Sided Colon Cancer across Four Decades: A Norwegian Population-Based Study.<h4>Background</h4>Patients with right-sided colon cancer (RCC) and left-sided colon cancer (LCC) differ clinically and molecularly. The main objective was to investigate stage-stratified survival and recurrence of RCC and LCC across four 10-year periods.<h4>Methods</h4>Patients diagnosed from 1977 to 2016 with colon adenocarcinoma were included from the Cancer Registry of Norway. Primary tumor location (PTL) was defined as RCC if proximal and LCC if distal to the splenic flexure. Multivariable regressions were used to estimate HRs for overall survival (OS), recurrence-free survival (RFS), survival after recurrence (SAR), and excess HRs (eHR) for relative survival (RS).<h4>Results</h4>72,224 patients were eligible for analyses [55.1% (<i>n</i> = 39,769/72,224) had RCC]. In 1977 to 1986, th2022-01-01T00:00:00Z2022 Feb2025-04-26T02:03:52.067Z2025-04-06T10:18:55.377ZS-EPMC93981283485302210.1158/1055-9965.EPI-21-0555