biostudies-literatureXu CKey Project of the National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Science and Technology Major Project1441-1453https://www.ebi.ac.uk/biostudies/studies/S-EPMC9398136biostudies-literatureUnknown19(9)Arginyltransferase (ATE1) plays critical roles in many biological functions including cardiovascular development, angiogenesis, adipogenesis, muscle contraction, and metastasis of cancer. However, the role of ATE1 in hepatocellular carcinoma (HCC) remains unknown. In this study, we find that ATE1 plays an essential role in growth and malignancy of liver cancer. ATE1 expression is significantly reduced in human HCC samples compared with normal liver tissue. In addition, low ATE1 expression is correlated with aggressive clinicopathologic features and is an independent poor prognostic factor for overall survival and disease-free survival of patients with HCC. Lentivirus-mediated ATE1 knockdown significantly promoted liver cancer growth, migration, and disease progression <i>in vitro</i> and <Molecular cancer research : MCRATE1 Inhibits Liver Cancer Progression through RGS5-Mediated Suppression of Wnt/β-Catenin Signaling.PMC93981362017ZX10203207–002–0038177313981330057Yang LYZhong FJSun BLi YMXu CfalseATE1 Inhibits Liver Cancer Progression through RGS5-Mediated Suppression of Wnt/β-Catenin Signaling.Arginyltransferase (ATE1) plays critical roles in many biological functions including cardiovascular development, angiogenesis, adipogenesis, muscle contraction, and metastasis of cancer. However, the role of ATE1 in hepatocellular carcinoma (HCC) remains unknown. In this study, we find that ATE1 plays an essential role in growth and malignancy of liver cancer. ATE1 expression is significantly reduced in human HCC samples compared with normal liver tissue. In addition, low ATE1 expression is correlated with aggressive clinicopathologic features and is an independent poor prognostic factor for overall survival and disease-free survival of patients with HCC. Lentivirus-mediated ATE1 knockdown significantly promoted liver cancer growth, migration, and disease progression <i>in vitro</i> and <2021-01-01T00:00:00Z2021 Sep2025-04-04T13:08:39.376Z2025-04-04T13:08:39.376ZS-EPMC93981363415839510.1158/1541-7786.MCR-21-0027