{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Brouwer KLR"],"funding":["NCI NIH HHS","National Institutes of Health","NIGMS NIH HHS"],"pagination":["461-484"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9398928"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["112(3)"],"pubmed_abstract":["Membrane transport proteins are involved in the absorption, disposition, efficacy, and/or toxicity of many drugs. Numerous mechanisms (e.g., nuclear receptors, epigenetic gene regulation, microRNAs, alternative splicing, post-translational modifications, and trafficking) regulate transport protein levels, localization, and function. Various factors associated with disease, medications, and dietary constituents, for example, may alter the regulation and activity of transport proteins in the intestine, liver, kidneys, brain, lungs, placenta, and other important sites, such as tumor tissue. This white paper reviews key mechanisms and regulatory factors that alter the function of clinically relevant transport proteins involved in drug disposition. Current considerations with in vitro and in vi"],"journal":["Clinical pharmacology and therapeutics"],"pubmed_title":["Regulation of Drug Transport Proteins-From Mechanisms to Clinical Impact: A White Paper on Behalf of the International Transporter Consortium."],"pmcid":["PMC9398928"],"funding_grant_id":["R35 GM122576","R01 GM139936","1R01GM139936‐01A1","R01 CA238946","R01CA238946"],"pubmed_authors":["Hu S","Meyer Zu Schwabedissen HE","Li CY","Evers R","Brouwer KLR","Sprowl JA","Saran C","Hayden E","Piquette-Miller M","Sjostedt N","Stahl SH","Neuhoff S","Oswald S","Yue W"],"additional_accession":[]},"is_claimable":false,"name":"Regulation of Drug Transport Proteins-From Mechanisms to Clinical Impact: A White Paper on Behalf of the International Transporter Consortium.","description":"Membrane transport proteins are involved in the absorption, disposition, efficacy, and/or toxicity of many drugs. Numerous mechanisms (e.g., nuclear receptors, epigenetic gene regulation, microRNAs, alternative splicing, post-translational modifications, and trafficking) regulate transport protein levels, localization, and function. Various factors associated with disease, medications, and dietary constituents, for example, may alter the regulation and activity of transport proteins in the intestine, liver, kidneys, brain, lungs, placenta, and other important sites, such as tumor tissue. This white paper reviews key mechanisms and regulatory factors that alter the function of clinically relevant transport proteins involved in drug disposition. Current considerations with in vitro and in vi","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2026-06-01T02:09:54.865Z","creation":"2025-02-19T01:28:14.626Z"},"accession":"S-EPMC9398928","cross_references":{"pubmed":["35390174"],"doi":["10.1002/cpt.2605"]}}