{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Bai Q"],"pubmed_abstract":["<h4>Background</h4>N6-methyladenosine (m6A) modification is a critical epigenetic modification in eukaryotes and involves several biological processes and occurrences of diseases. However, the roles and regulatory mechanisms of m6A regulators in osteoporosis (OP) remain unclear. Thus, the purpose of this study is to explore the roles and mechanisms of m6A regulators in OP.<h4>Methods</h4>The mRNA and microRNA (miRNA) expression profiles were respectively obtained from GSE56815, GSE7158, and GSE93883 datasets in Gene Expression Omnibus (GEO). The differential expression of 21 m6A regulators between high-bone mineral density (BMD) and low-BMD women was identified. Then, a consensus clustering of low-BMD women was performed based on differentially expressed (DE)-m6A regulators. The m6A-relate"],"journal":["Frontiers in endocrinology"],"pagination":["957742"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9399504"],"repository":["biostudies-literature"],"pubmed_title":["Comprehensive analysis of the m6A-related molecular patterns and diagnostic biomarkers in osteoporosis."],"pmcid":["PMC9399504"],"pubmed_authors":["Lou Q","Peng H","Shi M","Dai L","Bai Q","Fan J","Qu Z","Sun X"],"additional_accession":[]},"is_claimable":false,"name":"Comprehensive analysis of the m6A-related molecular patterns and diagnostic biomarkers in osteoporosis.","description":"<h4>Background</h4>N6-methyladenosine (m6A) modification is a critical epigenetic modification in eukaryotes and involves several biological processes and occurrences of diseases. However, the roles and regulatory mechanisms of m6A regulators in osteoporosis (OP) remain unclear. Thus, the purpose of this study is to explore the roles and mechanisms of m6A regulators in OP.<h4>Methods</h4>The mRNA and microRNA (miRNA) expression profiles were respectively obtained from GSE56815, GSE7158, and GSE93883 datasets in Gene Expression Omnibus (GEO). The differential expression of 21 m6A regulators between high-bone mineral density (BMD) and low-BMD women was identified. Then, a consensus clustering of low-BMD women was performed based on differentially expressed (DE)-m6A regulators. The m6A-relate","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-06-01T02:20:58.962Z","creation":"2025-04-04T14:21:14.902Z"},"accession":"S-EPMC9399504","cross_references":{"pubmed":["36034449"],"doi":["10.3389/fendo.2022.957742"]}}