biostudies-literatureLalli DUniversit? degli Studi del Piemonte OrientaleMinistero dell'Universit? e della Ricerca13199-13209https://www.ebi.ac.uk/biostudies/studies/S-EPMC9400103biostudies-literatureUnknown61(33)The GdAAZTA (AAZTA = 6-amino-6-methylperhydro-1,4-diazepinetetraacetic acid) complex represents a platform of great interest for the design of innovative MRI probes due to its remarkable magnetic properties, thermodynamic stability, kinetic inertness, and high chemical versatility. Here, we detail the synthesis and characterization of new derivatives functionalized with four amino acids with different molecular weights and charges: l-serine, l-cysteine, l-lysine, and l-glutamic acid. The main reason for conjugating these moieties to the ligand AAZTA is the in-depth study of the chemical properties in aqueous solution of model compounds that mimic complex structures based on polypeptide fragments used in molecular imaging applications. The analysis of the ¹H NMR spectra of the coInorganic chemistryDerivatives of GdAAZTA Conjugated to Amino Acids: A Multinuclear and Multifrequency NMR Study.PMC9400103FAR2017FAR2019PRIN 2017A2KEPLRicci MCarniato FHawala ID'Andrea LDTei LLalli DBotta MfalseDerivatives of GdAAZTA Conjugated to Amino Acids: A Multinuclear and Multifrequency NMR Study.The GdAAZTA (AAZTA = 6-amino-6-methylperhydro-1,4-diazepinetetraacetic acid) complex represents a platform of great interest for the design of innovative MRI probes due to its remarkable magnetic properties, thermodynamic stability, kinetic inertness, and high chemical versatility. Here, we detail the synthesis and characterization of new derivatives functionalized with four amino acids with different molecular weights and charges: l-serine, l-cysteine, l-lysine, and l-glutamic acid. The main reason for conjugating these moieties to the ligand AAZTA is the in-depth study of the chemical properties in aqueous solution of model compounds that mimic complex structures based on polypeptide fragments used in molecular imaging applications. The analysis of the ¹H NMR spectra of the co2022-01-01T00:00:00Z2022 Aug2025-04-05T15:18:20.794Z2025-02-19T00:41:54.083ZS-EPMC94001033594403410.1021/acs.inorgchem.2c02110