biostudies-literatureUnknown12Willadsen TG<h4>Background</h4>Multimorbidity is associated with increased mortality. Certain combinations of diseases are known to be more lethal than others, but the limited knowledge of how the chronology in which diseases develop impacts mortality may impair the development of effective clinical interventions for patients with multimorbidity.<h4>Objective</h4>To explore if in multimorbidity the chronology of disease onset is associated with mortality. Design: A prospective nationwide cohort study, including 3,986,209 people aged ≥18 years on 1 January 2000, was performed. We included ten diagnosis groups: lung, musculoskeletal, endocrine, mental, cancer, neurological, gastrointestinal, cardiovascular, kidney, and sensory organs. We defined multimorbidity as the presence of at least two diagnoses fJournal of multimorbidity and comorbidity26335565221122025https://www.ebi.ac.uk/biostudies/studies/S-EPMC9400403biostudies-literatureThe effect of disease onset chronology on mortality among patients with multimorbidity: A Danish nationwide register study.PMC9400403Koster-Rasmussen RSiersma VWilladsen TGRozing MReventlow SNicolaisdottir DRfalseThe effect of disease onset chronology on mortality among patients with multimorbidity: A Danish nationwide register study.<h4>Background</h4>Multimorbidity is associated with increased mortality. Certain combinations of diseases are known to be more lethal than others, but the limited knowledge of how the chronology in which diseases develop impacts mortality may impair the development of effective clinical interventions for patients with multimorbidity.<h4>Objective</h4>To explore if in multimorbidity the chronology of disease onset is associated with mortality. Design: A prospective nationwide cohort study, including 3,986,209 people aged ≥18 years on 1 January 2000, was performed. We included ten diagnosis groups: lung, musculoskeletal, endocrine, mental, cancer, neurological, gastrointestinal, cardiovascular, kidney, and sensory organs. We defined multimorbidity as the presence of at least two diagnoses f2022-01-01T00:00:00Z2022 Jan-Dec2025-06-01T02:00:35.315Z2024-12-04T01:10:18.72ZS-EPMC94004033603218410.1177/26335565221122025