{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["56(3)"],"submitter":["Zubair H"],"pubmed_abstract":["<h4>Background</h4>AKT, also called protein kinase B, is a serine-threonine kinase that functions as a mediator of PI3K-Akt-mTOR signaling pathway and plays an important role in an array of cellular processes. Many single nucleotide polymorphisms (SNP) in <i>AKT</i> gene have been observed to be associated with various types of cancers. In the current research the association of a functional SNP rs1130233 in <i>AKT</i>, depicting G to A transition, was studied with AKT activation, DNA damage, an early response B-cell translocation gene 2 (Btg2) expression and risk of colorectal cancer (CRC) development.<h4>Patients and methods</h4>A total 197 population-based controls and 200 CRC patients were genotyped for SNP rs1130233. AKT expression, activation and <i>BTG2</i> expression were determine"],"journal":["Radiology and oncology"],"pagination":["336-345"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9400445"],"repository":["biostudies-literature"],"pubmed_title":["Impact of <i>AKT1</i> polymorphism on DNA damage, <i>BTG2</i> expression, and risk of colorectal cancer development."],"pmcid":["PMC9400445"],"pubmed_authors":["Imran M","Khan Z","Zubair H"],"additional_accession":[]},"is_claimable":false,"name":"Impact of <i>AKT1</i> polymorphism on DNA damage, <i>BTG2</i> expression, and risk of colorectal cancer development.","description":"<h4>Background</h4>AKT, also called protein kinase B, is a serine-threonine kinase that functions as a mediator of PI3K-Akt-mTOR signaling pathway and plays an important role in an array of cellular processes. Many single nucleotide polymorphisms (SNP) in <i>AKT</i> gene have been observed to be associated with various types of cancers. In the current research the association of a functional SNP rs1130233 in <i>AKT</i>, depicting G to A transition, was studied with AKT activation, DNA damage, an early response B-cell translocation gene 2 (Btg2) expression and risk of colorectal cancer (CRC) development.<h4>Patients and methods</h4>A total 197 population-based controls and 200 CRC patients were genotyped for SNP rs1130233. AKT expression, activation and <i>BTG2</i> expression were determine","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Aug","modification":"2025-04-25T23:37:18.298Z","creation":"2024-11-06T18:45:58.304Z"},"accession":"S-EPMC9400445","cross_references":{"pubmed":["35962953"],"doi":["10.2478/raon-2022-0031"]}}