biostudies-literatureUnknown56(3)Zubair H<h4>Background</h4>AKT, also called protein kinase B, is a serine-threonine kinase that functions as a mediator of PI3K-Akt-mTOR signaling pathway and plays an important role in an array of cellular processes. Many single nucleotide polymorphisms (SNP) in <i>AKT</i> gene have been observed to be associated with various types of cancers. In the current research the association of a functional SNP rs1130233 in <i>AKT</i>, depicting G to A transition, was studied with AKT activation, DNA damage, an early response B-cell translocation gene 2 (Btg2) expression and risk of colorectal cancer (CRC) development.<h4>Patients and methods</h4>A total 197 population-based controls and 200 CRC patients were genotyped for SNP rs1130233. AKT expression, activation and <i>BTG2</i> expression were determineRadiology and oncology336-345https://www.ebi.ac.uk/biostudies/studies/S-EPMC9400445biostudies-literatureImpact of <i>AKT1</i> polymorphism on DNA damage, <i>BTG2</i> expression, and risk of colorectal cancer development.PMC9400445Imran MKhan ZZubair HfalseImpact of <i>AKT1</i> polymorphism on DNA damage, <i>BTG2</i> expression, and risk of colorectal cancer development.<h4>Background</h4>AKT, also called protein kinase B, is a serine-threonine kinase that functions as a mediator of PI3K-Akt-mTOR signaling pathway and plays an important role in an array of cellular processes. Many single nucleotide polymorphisms (SNP) in <i>AKT</i> gene have been observed to be associated with various types of cancers. In the current research the association of a functional SNP rs1130233 in <i>AKT</i>, depicting G to A transition, was studied with AKT activation, DNA damage, an early response B-cell translocation gene 2 (Btg2) expression and risk of colorectal cancer (CRC) development.<h4>Patients and methods</h4>A total 197 population-based controls and 200 CRC patients were genotyped for SNP rs1130233. AKT expression, activation and <i>BTG2</i> expression were determine2022-01-01T00:00:00Z2022 Aug2025-04-25T23:37:18.298Z2024-11-06T18:45:58.304ZS-EPMC94004453596295310.2478/raon-2022-0031