{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["23(15)"],"submitter":["Liang Y"],"pubmed_abstract":["Ribonuclease S (RNase S) is an enzyme that exhibits anticancer activity by degrading RNAs within cancer cells; however, the cellular uptake efficiency is low due to its small molecular size. Here we generated RNase S-decorated artificial viral capsids with a size of 70-170 nm by self-assembly of the β-annulus-S-peptide followed by reconstitution with S-protein at neutral pH. The RNase S-decorated artificial viral capsids are efficiently taken up by HepG2 cells and exhibit higher RNA degradation activity in cells compared with RNase S alone. Cell viability assays revealed that RNase S-decorated capsids have high anticancer activity comparable to that of standard anticancer drugs."],"journal":["Chembiochem : a European journal of chemical biology"],"pagination":["e202200220"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9400862"],"repository":["biostudies-literature"],"pubmed_title":["Anticancer Activity of Reconstituted Ribonuclease S-Decorated Artificial Viral Capsid."],"pmcid":["PMC9400862"],"pubmed_authors":["Inaba H","Furukawa H","Liang Y","Sakamoto K","Matsuura K"],"additional_accession":[]},"is_claimable":false,"name":"Anticancer Activity of Reconstituted Ribonuclease S-Decorated Artificial Viral Capsid.","description":"Ribonuclease S (RNase S) is an enzyme that exhibits anticancer activity by degrading RNAs within cancer cells; however, the cellular uptake efficiency is low due to its small molecular size. Here we generated RNase S-decorated artificial viral capsids with a size of 70-170 nm by self-assembly of the β-annulus-S-peptide followed by reconstitution with S-protein at neutral pH. The RNase S-decorated artificial viral capsids are efficiently taken up by HepG2 cells and exhibit higher RNA degradation activity in cells compared with RNase S alone. Cell viability assays revealed that RNase S-decorated capsids have high anticancer activity comparable to that of standard anticancer drugs.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Aug","modification":"2025-04-04T03:26:13.82Z","creation":"2025-04-04T03:26:13.82Z"},"accession":"S-EPMC9400862","cross_references":{"pubmed":["35676201"],"doi":["10.1002/cbic.202200220"]}}