biostudies-literatureWatson EESwiss National Science Foundatione202203390https://www.ebi.ac.uk/biostudies/studies/S-EPMC9400970biostudies-literatureUnknown61(28)A Ru(bpy)<sub>3</sub> Cl<sub>2</sub> photocatalyst is applied to the rapid trans to cis isomerization of a range of alkene-containing pharmacological agents, including combretastatin A-4 (CA-4), a clinical candidate in oncology, and resveratrol derivatives, switching their configuration from inactive substances to potent cytotoxic agents. Selective in cellulo activation of the CA-4 analog Res-3M is demonstrated, along with its potent cytotoxicity and inhibition of microtubule dynamics.Angewandte Chemie (International ed. in English)Optochemical Control of Therapeutic Agents through Photocatalyzed Isomerization.PMC9400970188406Russo FWatson EEMoreau DWinssinger NfalseOptochemical Control of Therapeutic Agents through Photocatalyzed Isomerization.A Ru(bpy)<sub>3</sub> Cl<sub>2</sub> photocatalyst is applied to the rapid trans to cis isomerization of a range of alkene-containing pharmacological agents, including combretastatin A-4 (CA-4), a clinical candidate in oncology, and resveratrol derivatives, switching their configuration from inactive substances to potent cytotoxic agents. Selective in cellulo activation of the CA-4 analog Res-3M is demonstrated, along with its potent cytotoxicity and inhibition of microtubule dynamics.2022-01-01T00:00:00Z2022 Jul2024-11-15T22:44:01.548Z2024-11-15T22:44:01.548ZS-EPMC94009703551030610.1002/anie.202203390