{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rockall AG"],"funding":["Medical Research Council Department of Health","Cancer Research UK","National Institute for Health Research (NIHR)"],"pagination":["6457-6466"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9401562"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["27(23)"],"pubmed_abstract":["<h4>Purpose</h4>Preoperative nodal staging is important for planning treatment in cervical cancer and endometrial cancer, but remains challenging. We compare nodal staging accuracy of <sup>18</sup>F-ethyl-choline-(FEC)-PET/CT, <sup>18</sup>F-fluoro-deoxy-glucose-(FDG)-PET/CT, and diffusion-weighted-MRI (DW-MRI) with conventional morphologic MRI.<h4>Experimental design</h4>A prospective, multicenter observational study of diagnostic accuracy for nodal metastases was undertaken in 5 gyne-oncology centers. FEC-PET/CT, FDG-PET/CT, and DW-MRI were compared with nodal size and morphology on MRI. Reference standard was strictly correlated nodal histology. Eligibility included operable cervical cancer stage ≥ 1B1 or endometrial cancer (grade 3 any stage with myometrial invasion or grade 1-2 stage "],"journal":["Clinical cancer research : an official journal of the American Association for Cancer Research"],"pubmed_title":["Diagnostic Accuracy of FEC-PET/CT, FDG-PET/CT, and Diffusion-Weighted MRI in Detection of Nodal Metastases in Surgically Treated Endometrial and Cervical Carcinoma."],"pmcid":["PMC9401562"],"funding_grant_id":["C444/A15953","12783","C1519/A16463"],"pubmed_authors":["Vosper L","Attygalle A","Koh DM","Sundar S","Stringfellow H","Wilson W","De Paepe KN","Ind T","Barton D","Dina R","Oram D","Ghaem-Maghami S","Ganesan R","Nobbenhuis M","Singh N","Fotopoulou C","Butler J","Kyrgiou M","Sahdev A","Warbey V","Taylor A","Coetzee C","Hill J","Lalondrelle S","Manchanda R","Lawrence A","Rockall AG","Cook GJ","Brockbank E","Hackshaw A","Bharwani N","Miquel M","Yazbek J","Stewart V","Guest P","MAPPING Study Group","Dobson M","Jeyarajah A","Zerizer I","Rosof-Williams D","Davies M","Hazell S","Farthing A","Barwick TD","Sohaib A","Martin-Hirsch P"],"additional_accession":[]},"is_claimable":false,"name":"Diagnostic Accuracy of FEC-PET/CT, FDG-PET/CT, and Diffusion-Weighted MRI in Detection of Nodal Metastases in Surgically Treated Endometrial and Cervical Carcinoma.","description":"<h4>Purpose</h4>Preoperative nodal staging is important for planning treatment in cervical cancer and endometrial cancer, but remains challenging. We compare nodal staging accuracy of <sup>18</sup>F-ethyl-choline-(FEC)-PET/CT, <sup>18</sup>F-fluoro-deoxy-glucose-(FDG)-PET/CT, and diffusion-weighted-MRI (DW-MRI) with conventional morphologic MRI.<h4>Experimental design</h4>A prospective, multicenter observational study of diagnostic accuracy for nodal metastases was undertaken in 5 gyne-oncology centers. FEC-PET/CT, FDG-PET/CT, and DW-MRI were compared with nodal size and morphology on MRI. Reference standard was strictly correlated nodal histology. Eligibility included operable cervical cancer stage ≥ 1B1 or endometrial cancer (grade 3 any stage with myometrial invasion or grade 1-2 stage ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2026-06-01T13:55:37.368Z","creation":"2026-04-08T13:10:13.366Z"},"accession":"S-EPMC9401562","cross_references":{"pubmed":["34526364"],"doi":["10.1158/1078-0432.CCR-21-1834"]}}