biostudies-literatureRockall AGMedical Research Council Department of HealthCancer Research UKNational Institute for Health Research (NIHR)6457-6466https://www.ebi.ac.uk/biostudies/studies/S-EPMC9401562biostudies-literatureUnknown27(23)<h4>Purpose</h4>Preoperative nodal staging is important for planning treatment in cervical cancer and endometrial cancer, but remains challenging. We compare nodal staging accuracy of ¹⁸F-ethyl-choline-(FEC)-PET/CT, ¹⁸F-fluoro-deoxy-glucose-(FDG)-PET/CT, and diffusion-weighted-MRI (DW-MRI) with conventional morphologic MRI.<h4>Experimental design</h4>A prospective, multicenter observational study of diagnostic accuracy for nodal metastases was undertaken in 5 gyne-oncology centers. FEC-PET/CT, FDG-PET/CT, and DW-MRI were compared with nodal size and morphology on MRI. Reference standard was strictly correlated nodal histology. Eligibility included operable cervical cancer stage ≥ 1B1 or endometrial cancer (grade 3 any stage with myometrial invasion or grade 1-2 stage Clinical cancer research : an official journal of the American Association for Cancer ResearchDiagnostic Accuracy of FEC-PET/CT, FDG-PET/CT, and Diffusion-Weighted MRI in Detection of Nodal Metastases in Surgically Treated Endometrial and Cervical Carcinoma.PMC9401562C444/A1595312783C1519/A16463Vosper LAttygalle AKoh DMSundar SStringfellow HWilson WDe Paepe KNInd TBarton DDina ROram DGhaem-Maghami SGanesan RNobbenhuis MSingh NFotopoulou CButler JKyrgiou MSahdev AWarbey VTaylor ACoetzee CHill JLalondrelle SManchanda RLawrence ARockall AGCook GJBrockbank EHackshaw ABharwani NMiquel MYazbek JStewart VGuest PMAPPING Study GroupDobson MJeyarajah AZerizer IRosof-Williams DDavies MHazell SFarthing ABarwick TDSohaib AMartin-Hirsch PfalseDiagnostic Accuracy of FEC-PET/CT, FDG-PET/CT, and Diffusion-Weighted MRI in Detection of Nodal Metastases in Surgically Treated Endometrial and Cervical Carcinoma.<h4>Purpose</h4>Preoperative nodal staging is important for planning treatment in cervical cancer and endometrial cancer, but remains challenging. We compare nodal staging accuracy of ¹⁸F-ethyl-choline-(FEC)-PET/CT, ¹⁸F-fluoro-deoxy-glucose-(FDG)-PET/CT, and diffusion-weighted-MRI (DW-MRI) with conventional morphologic MRI.<h4>Experimental design</h4>A prospective, multicenter observational study of diagnostic accuracy for nodal metastases was undertaken in 5 gyne-oncology centers. FEC-PET/CT, FDG-PET/CT, and DW-MRI were compared with nodal size and morphology on MRI. Reference standard was strictly correlated nodal histology. Eligibility included operable cervical cancer stage ≥ 1B1 or endometrial cancer (grade 3 any stage with myometrial invasion or grade 1-2 stage 2021-01-01T00:00:00Z2021 Dec2026-06-01T13:55:37.368Z2026-04-08T13:10:13.366ZS-EPMC94015623452636410.1158/1078-0432.CCR-21-1834