biostudies-literatureBychek REuropean Research CouncilHORIZON EUROPE European Research Councile202205103https://www.ebi.ac.uk/biostudies/studies/S-EPMC9401599biostudies-literatureUnknown61(29)After more than 20 years of trials, a practical scalable approach to fluoro-substituted bicyclo[1.1.1]pentanes (F-BCPs) has been developed. The physicochemical properties of the F-BCPs have been studied, and the core was incorporated into the structure of the anti-inflammatory drug Flurbiprofen in place of the fluorophenyl ring.Angewandte Chemie (International ed. in English)A Practical and Scalable Approach to Fluoro-Substituted Bicyclo[1.1.1]pentanes.PMC9401599101000893Mykhailiuk PKBychek RfalseA Practical and Scalable Approach to Fluoro-Substituted Bicyclo[1.1.1]pentanes.After more than 20 years of trials, a practical scalable approach to fluoro-substituted bicyclo[1.1.1]pentanes (F-BCPs) has been developed. The physicochemical properties of the F-BCPs have been studied, and the core was incorporated into the structure of the anti-inflammatory drug Flurbiprofen in place of the fluorophenyl ring.2022-01-01T00:00:00Z2022 Jul2025-06-01T01:32:28.548Z2025-06-01T01:32:28.548ZS-EPMC94015993563840410.1002/anie.202205103