{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["19(6)"],"submitter":["Li Y"],"funding":["Hubei Province Natural Science Foundation","National Natural Science Foundation of China"],"pubmed_abstract":["Sex reversal, representing extraordinary sexual plasticity during the life cycle, not only triggers reproduction in animals but also affects reproductive and endocrine system-related diseases and cancers in humans. Sex reversal has been broadly reported in animals; however, an integrated resource hub of sex reversal information is still lacking. Here, we constructed a comprehensive database named ASER (Animal Sex Reversal) by integrating sex reversal-related data of 18 species from teleostei to mammalia. We systematically collected 40,018 published papers and mined the sex reversal-associated genes (SRGs), including their regulatory networks, from 1611 core papers. We annotated homologous genes and computed conservation scores for whole genomes across the 18 species. Furthermore, we collec"],"journal":["Genomics, proteomics & bioinformatics"],"pagination":["873-881"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9402789"],"repository":["biostudies-literature"],"pubmed_title":["ASER: Animal Sex Reversal Database."],"pmcid":["PMC9402789"],"pubmed_authors":["Liu H","Fan W","Zhu Z","Hu W","Lin X","Li Q","Li R","Zhou Y","Luo D","Ji S","Li Y","Li S","Chen Z","Zhao H"],"additional_accession":[]},"is_claimable":false,"name":"ASER: Animal Sex Reversal Database.","description":"Sex reversal, representing extraordinary sexual plasticity during the life cycle, not only triggers reproduction in animals but also affects reproductive and endocrine system-related diseases and cancers in humans. Sex reversal has been broadly reported in animals; however, an integrated resource hub of sex reversal information is still lacking. Here, we constructed a comprehensive database named ASER (Animal Sex Reversal) by integrating sex reversal-related data of 18 species from teleostei to mammalia. We systematically collected 40,018 published papers and mined the sex reversal-associated genes (SRGs), including their regulatory networks, from 1611 core papers. We annotated homologous genes and computed conservation scores for whole genomes across the 18 species. Furthermore, we collec","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2025-04-19T01:36:13.805Z","creation":"2025-04-07T12:20:13.704Z"},"accession":"S-EPMC9402789","cross_references":{"pubmed":["34839012"],"doi":["10.1016/j.gpb.2021.10.001"]}}