biostudies-literatureUnknown19(6)Li YHubei Province Natural Science FoundationNational Natural Science Foundation of ChinaSex reversal, representing extraordinary sexual plasticity during the life cycle, not only triggers reproduction in animals but also affects reproductive and endocrine system-related diseases and cancers in humans. Sex reversal has been broadly reported in animals; however, an integrated resource hub of sex reversal information is still lacking. Here, we constructed a comprehensive database named ASER (Animal Sex Reversal) by integrating sex reversal-related data of 18 species from teleostei to mammalia. We systematically collected 40,018 published papers and mined the sex reversal-associated genes (SRGs), including their regulatory networks, from 1611 core papers. We annotated homologous genes and computed conservation scores for whole genomes across the 18 species. Furthermore, we collecGenomics, proteomics & bioinformatics873-881https://www.ebi.ac.uk/biostudies/studies/S-EPMC9402789biostudies-literatureASER: Animal Sex Reversal Database.PMC9402789Liu HFan WZhu ZHu WLin XLi QLi RZhou YLuo DJi SLi YLi SChen ZZhao HfalseASER: Animal Sex Reversal Database.Sex reversal, representing extraordinary sexual plasticity during the life cycle, not only triggers reproduction in animals but also affects reproductive and endocrine system-related diseases and cancers in humans. Sex reversal has been broadly reported in animals; however, an integrated resource hub of sex reversal information is still lacking. Here, we constructed a comprehensive database named ASER (Animal Sex Reversal) by integrating sex reversal-related data of 18 species from teleostei to mammalia. We systematically collected 40,018 published papers and mined the sex reversal-associated genes (SRGs), including their regulatory networks, from 1611 core papers. We annotated homologous genes and computed conservation scores for whole genomes across the 18 species. Furthermore, we collec2021-01-01T00:00:00Z2021 Dec2025-04-19T01:36:13.805Z2025-04-07T12:20:13.704ZS-EPMC94027893483901210.1016/j.gpb.2021.10.001