{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Duarte RRR"],"funding":["NIDA NIH HHS","NIA NIH HHS","NIAID NIH HHS","NIDCD NIH HHS","Medical Research Council","NHGRI NIH HHS"],"pagination":["104854"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9403347"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(9)"],"pubmed_abstract":["The host genetic factors conferring protection against HIV type 1 (HIV-1) acquisition remain elusive, and in particular the contributions of common genetic variants. Here, we performed the largest genome-wide association meta-analysis of HIV-1 acquisition, which included 7,303 HIV-1-positive individuals and 587,343 population controls. We identified 25 independent genetic loci with suggestive association, of which one was genome-wide significant within the major histocompatibility complex (MHC) locus. After exclusion of the MHC signal, linkage disequilibrium score regression analyses revealed a SNP heritability of 21% and genetic correlations with behavioral factors. A transcriptome-wide association study identified 15 susceptibility genes, including <i>HERC1</i>, <i>UEVLD</i>, and <i>HIST"],"journal":["iScience"],"pubmed_title":["Transcriptome-wide association study of HIV-1 acquisition identifies &lt;i&gt;HERC1&lt;/i&gt; as a susceptibility gene."],"pmcid":["PMC9403347"],"funding_grant_id":["R01 DC004212","MC_PC_17228","R01 AG004212","HHSN268200782096C","R21 AI154956","R01 DA009532","R01 DA026141","MC_QA137853"],"pubmed_authors":["Furler RL","Powell TR","Duarte RRR","Nixon DF","Pain O"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptome-wide association study of HIV-1 acquisition identifies &lt;i&gt;HERC1&lt;/i&gt; as a susceptibility gene.","description":"The host genetic factors conferring protection against HIV type 1 (HIV-1) acquisition remain elusive, and in particular the contributions of common genetic variants. Here, we performed the largest genome-wide association meta-analysis of HIV-1 acquisition, which included 7,303 HIV-1-positive individuals and 587,343 population controls. We identified 25 independent genetic loci with suggestive association, of which one was genome-wide significant within the major histocompatibility complex (MHC) locus. After exclusion of the MHC signal, linkage disequilibrium score regression analyses revealed a SNP heritability of 21% and genetic correlations with behavioral factors. A transcriptome-wide association study identified 15 susceptibility genes, including <i>HERC1</i>, <i>UEVLD</i>, and <i>HIST","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2026-05-09T03:16:41.972Z","creation":"2024-10-16T04:13:10.876Z"},"accession":"S-EPMC9403347","cross_references":{"pubmed":["36034232"],"doi":["10.1016/j.isci.2022.104854"]}}