biostudies-literatureUnknown12(9)Meng N<h4>Background</h4>Noninvasive assessment of programmed death-ligand 1 (PD-L1) expression status in non-small cell lung cancer (NSCLC) is necessary. This study arm to investigate the value of 2-[¹⁸F]-fluoro-2-deoxy-D-glucose positron emission tomography (¹⁸F-FDG PET), diffusion-weighted imaging (DWI), intravoxel incoherent motion (IVIM), and amide proton transfer-weighted imaging (APTWI) in the assessment of PD-L1 status in NSCLC.<h4>Methods</h4>This is a prospective diagnostic study. A total of 76 patients with NSCLC underwent chest ¹⁸F-FDG PET/magnetic resonance imaging (MRI). Parameters maximum standardized uptake value (SUV_max), quantitate the metabolic tumor volume (MTV), total lesion glycolysis (TLG), apparent diffusion coefficient (ADC), dQuantitative imaging in medicine and surgery4474-4487https://www.ebi.ac.uk/biostudies/studies/S-EPMC9403585biostudies-literatureSensitivity and specificity of amide proton transfer-weighted imaging for assessing programmed death-ligand 1 status in non-small cell lung cancer: a comparative study with intravoxel incoherent motion and ¹⁸F-FDG PET.PMC9403585Liu HWang MLi XYang YFu FMeng NLuo YWang ZSun JFeng PWu YYuan JfalseSensitivity and specificity of amide proton transfer-weighted imaging for assessing programmed death-ligand 1 status in non-small cell lung cancer: a comparative study with intravoxel incoherent motion and ¹⁸F-FDG PET.<h4>Background</h4>Noninvasive assessment of programmed death-ligand 1 (PD-L1) expression status in non-small cell lung cancer (NSCLC) is necessary. This study arm to investigate the value of 2-[¹⁸F]-fluoro-2-deoxy-D-glucose positron emission tomography (¹⁸F-FDG PET), diffusion-weighted imaging (DWI), intravoxel incoherent motion (IVIM), and amide proton transfer-weighted imaging (APTWI) in the assessment of PD-L1 status in NSCLC.<h4>Methods</h4>This is a prospective diagnostic study. A total of 76 patients with NSCLC underwent chest ¹⁸F-FDG PET/magnetic resonance imaging (MRI). Parameters maximum standardized uptake value (SUV_max), quantitate the metabolic tumor volume (MTV), total lesion glycolysis (TLG), apparent diffusion coefficient (ADC), d2022-01-01T00:00:00Z2022 Sep2025-04-05T12:32:09.848Z2024-11-10T06:28:15.055ZS-EPMC94035853606058410.21037/qims-22-189