biostudies-literatureUnknown7(10)Van Mieghem NM<h4>Importance</h4>In patients with severe aortic valve stenosis at intermediate surgical risk, transcatheter aortic valve replacement (TAVR) with a self-expanding supra-annular valve was noninferior to surgery for all-cause mortality or disabling stroke at 2 years. Comparisons of longer-term clinical and hemodynamic outcomes in these patients are limited.<h4>Objective</h4>To report prespecified secondary 5-year outcomes from the Symptomatic Aortic Stenosis in Intermediate Risk Subjects Who Need Aortic Valve Replacement (SURTAVI) randomized clinical trial.<h4>Design, setting, and participants</h4>SURTAVI is a prospective randomized, unblinded clinical trial. Randomization was stratified by investigational site and need for revascularization determined by the local heart teams. Patients witJAMA cardiology1000-1008https://www.ebi.ac.uk/biostudies/studies/S-EPMC9403849biostudies-literatureSelf-expanding Transcatheter vs Surgical Aortic Valve Replacement in Intermediate-Risk Patients: 5-Year Outcomes of the SURTAVI Randomized Clinical Trial.PMC9403849Edmonson SPolsani VGlower DLittle SBajwa TWorgan BEstrada KWatanabe CNanduri SMargey RRost IScheele MOplinger JTodd ARussell CWelz APlank BKonopka KKhalique OTaboada SBavbekova SRosenbloom MSundararajan JRuiter AWhite JWhite SYamasaki HYamasaki KHerder WMusarra RGulati DBradbury ECardozo MTemple AAmrane HLlosa Cortina JCMuehlebach GSantiago LLowery MLowery RGulati RReul REriksen EStader MMalkin CJBarry MBrinegar PRao SPhuong NAgarwal SPool-Owens CAAgarwal HSedaghat ADeutsch EMumtaz MSharma ASuch MSondergaard LNathan SMunir AOlds KNelson AReineke SBinder RRuest RSharma SSharma RBurke DBonomo RGoppel GSharma MSchuck LWilley JLimaye SSSanossian NMoye SArnold MDe La Hera JMLilly SPerchuk AHaegerl CJohnson RShawgo TYuh DWolf BTrautman LHager CMaier WRuge HGrey WDean DMoynihan BPayne JSpangler JLeavitt BDe Palma RStelzer PSegar DHoit Bde Lind van Wijngaarden RStuver TLanz JKeller DGandhi SPultrum MMetes MMendes LHessler CLeya FRocha MBonan RHan MFranzen OBack MCiprich CSchneider DBurkart JJahangiri MLammers DCrock FRodriguez Bailon ICarcedo BMittal STran THerbert NClarke BRuel MLoli ANkomo VMcGarvery MSiepe MChaloulos-Lakovidis PGick MMody CSilverman IJadoenath-Oedai SKennen JRichards DKutzke KGreene JMarcus RSalseth TBates MBenner AArshi APieter JNagueh SWirt Kvan Deutekom IMichel KBagur RPlestis KHazen PPraz FBavaria JAtapattu SGleason TGGreening KUnderwood CVerelst SGRBerke APerko MHarrison ARaney ATerrien ESadiq ILeshnower BChava SLund JAllaqaband SKipperman RKrupowies NVora NWanklyn PPrabhakar GBezerra HLogtens EShults CHarjai KZurcher FWeigand AHolubec TVora APerk GYakubov SFuchs AJohn HWarshal WRobison RSeto TSuma VAttubato MKoudstaal PJRinaldi MAlkhouli MHancock ASiki MBledsoe DPanaich SKatz 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ESURTAVI Trial InvestigatorsJadhav APershad APoppert HMoainie SAllen KAllen MMaisano FGenereux PPrice AMorales-Vidal SMoossavi SWeig LBrady KElijovich LWyler von Ballmoos MMazzurco SVelazquez EKirkland LKachoris JMardell SHettich IMedina Fernandez MBremer KPark SMisra AKhella SHoff SVannan MGuerin DLong DSwenson CNewbold SLiam DWillhide JEsposito RSiller KMalasana GMorin CBrunetti DPurrington EPunzalan RStaniloae CTerluin HFaheem OWinker TStreib CMueller-Kronast NGarimella SGonzales MGada HBeyersdorf FMcGargle RCampbell DIyengar PVolpi JfalseSelf-expanding Transcatheter vs Surgical Aortic Valve Replacement in Intermediate-Risk Patients: 5-Year Outcomes of the SURTAVI Randomized Clinical Trial.<h4>Importance</h4>In patients with severe aortic valve stenosis at intermediate surgical risk, transcatheter aortic valve replacement (TAVR) with a self-expanding supra-annular valve was noninferior to surgery for all-cause mortality or disabling stroke at 2 years. Comparisons of longer-term clinical and hemodynamic outcomes in these patients are limited.<h4>Objective</h4>To report prespecified secondary 5-year outcomes from the Symptomatic Aortic Stenosis in Intermediate Risk Subjects Who Need Aortic Valve Replacement (SURTAVI) randomized clinical trial.<h4>Design, setting, and participants</h4>SURTAVI is a prospective randomized, unblinded clinical trial. Randomization was stratified by investigational site and need for revascularization determined by the local heart teams. Patients wit2022-01-01T00:00:00Z2022 Oct2026-06-06T01:13:01.626Z2025-04-04T20:06:56.074ZS-EPMC94038493600133510.1001/jamacardio.2022.2695