biostudies-literatureUnknown10(8)Paganelli FThe evaluation of suspected coronary artery disease (CAD) in the medical community is challenging. Patients with suspected coronary chronic syndrome (CCS) are referred by the medical community to be assessed by specialists for the performance of noninvasive tests that have high rates of false positives and false negatives. While troponins are the gold standard for evaluate myocardial injuries, there is no biomarker to assess myocardial ischemia in patient populations with negative electrocardiography or without an increase in troponin level. A2A adenosine receptors control the coronary blood flow through its vasodilating properties. It has been shown that patients with CAD have a lower A2AR expression on peripheral blood mononuclear cells, suggesting a link between A2AR production and the Biomedicines1849https://www.ebi.ac.uk/biostudies/studies/S-EPMC9405059biostudies-literaturePlasma A_2AR Measurement Can Help Physicians Identify Patients Suspected of Coronary Chronic Syndrome: A Pilot Study.PMC9405059Aliouane SMottola GKipson NGuieu RMarlinge MMethlin LDeharo PGaudry MCriado CCappiello GNtawanga JRuf JPeroni ECarreno MPaganelli FFromonot JHamou KfalsePlasma A_2AR Measurement Can Help Physicians Identify Patients Suspected of Coronary Chronic Syndrome: A Pilot Study.The evaluation of suspected coronary artery disease (CAD) in the medical community is challenging. Patients with suspected coronary chronic syndrome (CCS) are referred by the medical community to be assessed by specialists for the performance of noninvasive tests that have high rates of false positives and false negatives. While troponins are the gold standard for evaluate myocardial injuries, there is no biomarker to assess myocardial ischemia in patient populations with negative electrocardiography or without an increase in troponin level. A2A adenosine receptors control the coronary blood flow through its vasodilating properties. It has been shown that patients with CAD have a lower A2AR expression on peripheral blood mononuclear cells, suggesting a link between A2AR production and the 2022-01-01T00:00:00Z2022 Aug2025-04-27T02:28:51.747Z2024-11-21T06:49:42.962ZS-EPMC94050593600939610.3390/biomedicines10081849