biostudies-literatureJin BBLRD VAUnited States Department of Veterans Affairs1976https://www.ebi.ac.uk/biostudies/studies/S-EPMC9405709biostudies-literatureUnknown10(8)Patients with psoriasis tend to develop skin cancer, and the hyperproliferation of the epidermis is a histopathological hallmark of both psoriasis and cutaneous squamous cell carcinoma (SCC), indicating that they may share pathogenic mechanisms. Interleukin-17 (IL17) stimulates the proliferation of the epidermis, leading to psoriasis. Overexpression of Polo-like kinase 4 (PLK4), which controls centriole duplication, has been identified in SCC, which also shows the hyperproliferation of keratinocytes. To investigate the cooperation between IL17 signaling and centriole duplication in epidermal proliferation, we established psoriasis and skin papilloma models in wild type (WT), IL17 receptor A (T779A) knockin (<i>Il17ra</i>(T779A)-KI), and IL17 receptor C knockout (<i>Il17rc</i>-KO) mouse strBiomedicinesDefect of IL17 Signaling, but Not Centrinone, Inhibits the Development of Psoriasis and Skin Papilloma in Mouse Models.PMC9405709I01 BX004158I01BX004158Miller HDGe DYou ZJin BZhang YHe LWang ARfalseDefect of IL17 Signaling, but Not Centrinone, Inhibits the Development of Psoriasis and Skin Papilloma in Mouse Models.Patients with psoriasis tend to develop skin cancer, and the hyperproliferation of the epidermis is a histopathological hallmark of both psoriasis and cutaneous squamous cell carcinoma (SCC), indicating that they may share pathogenic mechanisms. Interleukin-17 (IL17) stimulates the proliferation of the epidermis, leading to psoriasis. Overexpression of Polo-like kinase 4 (PLK4), which controls centriole duplication, has been identified in SCC, which also shows the hyperproliferation of keratinocytes. To investigate the cooperation between IL17 signaling and centriole duplication in epidermal proliferation, we established psoriasis and skin papilloma models in wild type (WT), IL17 receptor A (T779A) knockin (<i>Il17ra</i>(T779A)-KI), and IL17 receptor C knockout (<i>Il17rc</i>-KO) mouse str2022-01-01T00:00:00Z2022 Aug2025-04-27T02:29:42.228Z2024-11-21T06:49:39.675ZS-EPMC94057093600952310.3390/biomedicines10081976