{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wysocki O"],"funding":["Cancer Research UK","Digital biodesign and personalized healthcare","Medical Research Council","CRUK Core funding to Manchester Institute","CRUK Manchester Centre Award","The Liverpool Experimental Cancer Medicine Centre","National Institute for Health Research (NIHR)","National Institute for Health Research Health Protection Research Unit (HPRU) in Emerging and Zoonotic Infections","The Christie Charitable Fund","CRUK Accelerator Award","Wellcome Trust"],"pagination":["3931"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9406013"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(16)"],"pubmed_abstract":["Patients with cancer have been shown to have increased risk of COVID-19 severity. We previously built and validated the COVID-19 Risk in Oncology Evaluation Tool (CORONET) to predict the likely severity of COVID-19 in patients with active cancer who present to hospital. We assessed the differences in presentation and outcomes of patients with cancer and COVID-19, depending on the wave of the pandemic. We examined differences in features at presentation and outcomes in patients worldwide, depending on the waves of the pandemic: wave 1 D614G (n = 1430), wave 2 Alpha (n = 475), and wave 4 Omicron variant (n = 63, UK and Spain only). The performance of CORONET was evaluated on 258, 48, and 54 patients for each wave, respectively. We found that mortality rates were reduced in subsequent waves. "],"journal":["Cancers"],"pubmed_title":["An International Comparison of Presentation, Outcomes and CORONET Predictive Score Performance in Patients with Cancer Presenting with COVID-19 across Different Pandemic Waves."],"pmcid":["PMC9406013"],"funding_grant_id":["C5757/A27412","ACF-2019-04-005","S_3800","C5759/A25254","CL-2018-06-001","29569","MR/N025989/1","205228/Z/16/Z","NIHR202438","29374","75-15-2020-926","CL-2013-07-005","NIHR200907","CL-2020-06-003","C18616/A25153","CL-2018-11-002","1049751"],"pubmed_authors":["Castelo-Branco L","Frederiksen H","Lee RJ","Mosenthal AC","Dani SS","Bhogal T","Dickens E","Hague C","Jakobsen LH","Cooksley T","Aung T","Croitoru A","Peters S","Sheehan R","Baxter M","Joharatnam-Hogan N","Patel R","Rowe M","Britton F","Foulon S","Hoskins R","Sekacheva M","Armstrong AC","Barlesi F","Albiges L","Angelakas A","Landers D","Romano E","Boyce H","Weaver J","Tivey A","Turtle L","Graham DM","Lewis A","McKenzie H","Freitas A","Copson E","Williams S","Massard C","Dive C","Thomas A","Gomes F","Vinal D","Fitzpatrick P","Rogado J","Ganatra S","Palmieri C","Rieger-Christ K","On Behalf Of The Esmo Co-Care","Pentheroudakis G","Calles A","Zhou C","Arnold D","Harrison M","Besse B","Harrington K","Stockdale A","Eastlake L","Khan UT","Horsley L","Michielin O","Bayle A","Obispo B","Shotton R","Robinson T","Huddar P","Hudson Z","Banfill K","Maynard A","Wilson C","Gennatas S","Khan K","Wysocki O","Glenthoj A","Khan S"],"additional_accession":[]},"is_claimable":false,"name":"An International Comparison of Presentation, Outcomes and CORONET Predictive Score Performance in Patients with Cancer Presenting with COVID-19 across Different Pandemic Waves.","description":"Patients with cancer have been shown to have increased risk of COVID-19 severity. We previously built and validated the COVID-19 Risk in Oncology Evaluation Tool (CORONET) to predict the likely severity of COVID-19 in patients with active cancer who present to hospital. We assessed the differences in presentation and outcomes of patients with cancer and COVID-19, depending on the wave of the pandemic. We examined differences in features at presentation and outcomes in patients worldwide, depending on the waves of the pandemic: wave 1 D614G (n = 1430), wave 2 Alpha (n = 475), and wave 4 Omicron variant (n = 63, UK and Spain only). The performance of CORONET was evaluated on 258, 48, and 54 patients for each wave, respectively. We found that mortality rates were reduced in subsequent waves. ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Aug","modification":"2025-04-20T03:34:45.903Z","creation":"2024-11-15T17:07:58.038Z"},"accession":"S-EPMC9406013","cross_references":{"pubmed":["36010932"],"doi":["10.3390/cancers14163931"]}}