biostudies-literatureWysocki OCancer Research UKDigital biodesign and personalized healthcareMedical Research CouncilCRUK Core funding to Manchester InstituteCRUK Manchester Centre AwardThe Liverpool Experimental Cancer Medicine CentreNational Institute for Health Research (NIHR)National Institute for Health Research Health Protection Research Unit (HPRU) in Emerging and Zoonotic InfectionsThe Christie Charitable FundCRUK Accelerator AwardWellcome Trust3931https://www.ebi.ac.uk/biostudies/studies/S-EPMC9406013biostudies-literatureUnknown14(16)Patients with cancer have been shown to have increased risk of COVID-19 severity. We previously built and validated the COVID-19 Risk in Oncology Evaluation Tool (CORONET) to predict the likely severity of COVID-19 in patients with active cancer who present to hospital. We assessed the differences in presentation and outcomes of patients with cancer and COVID-19, depending on the wave of the pandemic. We examined differences in features at presentation and outcomes in patients worldwide, depending on the waves of the pandemic: wave 1 D614G (n = 1430), wave 2 Alpha (n = 475), and wave 4 Omicron variant (n = 63, UK and Spain only). The performance of CORONET was evaluated on 258, 48, and 54 patients for each wave, respectively. We found that mortality rates were reduced in subsequent waves. CancersAn International Comparison of Presentation, Outcomes and CORONET Predictive Score Performance in Patients with Cancer Presenting with COVID-19 across Different Pandemic Waves.PMC9406013C5757/A27412ACF-2019-04-005S_3800C5759/A25254CL-2018-06-00129569MR/N025989/1205228/Z/16/ZNIHR2024382937475-15-2020-926CL-2013-07-005NIHR200907CL-2020-06-003C18616/A25153CL-2018-11-0021049751Castelo-Branco LFrederiksen HLee RJMosenthal ACDani SSBhogal TDickens EHague CJakobsen LHCooksley TAung TCroitoru APeters SSheehan RBaxter MJoharatnam-Hogan NPatel RRowe MBritton FFoulon SHoskins RSekacheva MArmstrong ACBarlesi FAlbiges LAngelakas ALanders DRomano EBoyce HWeaver JTivey ATurtle LGraham DMLewis AMcKenzie HFreitas ACopson EWilliams SMassard CDive CThomas AGomes FVinal DFitzpatrick PRogado JGanatra SPalmieri CRieger-Christ KOn Behalf Of The Esmo Co-CarePentheroudakis GCalles AZhou CArnold DHarrison MBesse BHarrington KStockdale AEastlake LKhan UTHorsley LMichielin OBayle AObispo BShotton RRobinson THuddar PHudson ZBanfill KMaynard AWilson CGennatas SKhan KWysocki OGlenthoj AKhan SfalseAn International Comparison of Presentation, Outcomes and CORONET Predictive Score Performance in Patients with Cancer Presenting with COVID-19 across Different Pandemic Waves.Patients with cancer have been shown to have increased risk of COVID-19 severity. We previously built and validated the COVID-19 Risk in Oncology Evaluation Tool (CORONET) to predict the likely severity of COVID-19 in patients with active cancer who present to hospital. We assessed the differences in presentation and outcomes of patients with cancer and COVID-19, depending on the wave of the pandemic. We examined differences in features at presentation and outcomes in patients worldwide, depending on the waves of the pandemic: wave 1 D614G (n = 1430), wave 2 Alpha (n = 475), and wave 4 Omicron variant (n = 63, UK and Spain only). The performance of CORONET was evaluated on 258, 48, and 54 patients for each wave, respectively. We found that mortality rates were reduced in subsequent waves. 2022-01-01T00:00:00Z2022 Aug2025-04-20T03:34:45.903Z2024-11-15T17:07:58.038ZS-EPMC94060133601093210.3390/cancers14163931