{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Papadakis V"],"funding":["Association Hubert Gouin-Enfance et Cancer","French Society of Pediatric Oncology","European Union's Seventh Framework Programme","the Fédération Enfant &amp; Santé","European Union&apos;s Seventh Framework Programme","Fondazione Italiana per la Lotta al Neuroblastoma","Institute of Health Carlos III-General Subdirectorate for Evaluation and Promotion of Research"],"pagination":["4007"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9406882"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(16)"],"pubmed_abstract":["<b>Background:</b> To assess whether expectant observation of infants ≤ 90 days old with small suprarenal masses (sSRMs) could avoid unnecessary surgery without impacting outcome. <b>Methods:</b> Infants ≤ 90 days with a ≤ 5 cm mass, without midline extension or lymph node or distant spread were registered (ClinicalTrials.org:NCT01728155). Once staging was completed, they were followed with ultrasound, MRI and urinary catecholamines. Surgical resection was only planned if there was a ≥40% mass volume increase or for a mass persisting after 48 weeks of the planned observation. <b>Results:</b> Over a 5-year period, 128 infants were registered. No infant had detectable MYCN amplification in the peripheral blood. Surgery was performed in 39 (30.5%) patients, in 18 during and in 21 after the pl"],"journal":["Cancers"],"pubmed_title":["Suprarenal Masses in Very Young Infants: Is It Safe to Watch and Wait? Report of a SIOPEN Observational Study Results."],"pmcid":["PMC9406882"],"funding_grant_id":["PT13/0002/0032 and PT17/0017/0035","Italy","ENCCA_261474","France"],"pubmed_authors":["Ash S","Sarnacki S","Canete A","Schleiermacher G","Segura V","Brichard B","Granata C","Plantaz D","Conte M","Di Cataldo A","Papadakis V","Combaret V","Bermudez JD","Ladenstein R","Wheeler K","Fagnani AM"],"additional_accession":[]},"is_claimable":false,"name":"Suprarenal Masses in Very Young Infants: Is It Safe to Watch and Wait? Report of a SIOPEN Observational Study Results.","description":"<b>Background:</b> To assess whether expectant observation of infants ≤ 90 days old with small suprarenal masses (sSRMs) could avoid unnecessary surgery without impacting outcome. <b>Methods:</b> Infants ≤ 90 days with a ≤ 5 cm mass, without midline extension or lymph node or distant spread were registered (ClinicalTrials.org:NCT01728155). Once staging was completed, they were followed with ultrasound, MRI and urinary catecholamines. Surgical resection was only planned if there was a ≥40% mass volume increase or for a mass persisting after 48 weeks of the planned observation. <b>Results:</b> Over a 5-year period, 128 infants were registered. No infant had detectable MYCN amplification in the peripheral blood. Surgery was performed in 39 (30.5%) patients, in 18 during and in 21 after the pl","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Aug","modification":"2026-06-20T03:14:25.466Z","creation":"2024-10-16T04:12:06.004Z"},"accession":"S-EPMC9406882","cross_references":{"pubmed":["36011005"],"doi":["10.3390/cancers14164007"]}}