biostudies-literatureUnknown10Liu WFor the male genetic materials to reach and fertilize the egg, spermatozoa must contend with numerous environmental changes in a complex and highly sophisticated process from generation in the testis, and maturation in the epididymis to capacitation and fertilization. Taste is an ancient chemical sense that has an essential role in the animal's response to carbohydrates in the external environment and is involved in the body's energy perception. In recent years, numerous studies have confirmed that taste signaling factors (taste receptor families 1, 2 and their downstream molecules, Gα and PLCβ2) are distributed in testes and epididymis tissues outside the oral cavity. Their functions are directly linked to spermatogenesis, maturation, and fertilization, which are potential targets for regFrontiers in cell and developmental biology956981https://www.ebi.ac.uk/biostudies/studies/S-EPMC9407969biostudies-literatureTaste receptors affect male reproduction by influencing steroid synthesis.PMC9407969Gong TShi FChen XXu HLiu WfalseTaste receptors affect male reproduction by influencing steroid synthesis.For the male genetic materials to reach and fertilize the egg, spermatozoa must contend with numerous environmental changes in a complex and highly sophisticated process from generation in the testis, and maturation in the epididymis to capacitation and fertilization. Taste is an ancient chemical sense that has an essential role in the animal's response to carbohydrates in the external environment and is involved in the body's energy perception. In recent years, numerous studies have confirmed that taste signaling factors (taste receptor families 1, 2 and their downstream molecules, Gα and PLCβ2) are distributed in testes and epididymis tissues outside the oral cavity. Their functions are directly linked to spermatogenesis, maturation, and fertilization, which are potential targets for reg2022-01-01T00:00:00Z20222025-05-29T16:11:44.542Z2025-04-04T09:32:09.531ZS-EPMC94079693603599210.3389/fcell.2022.956981