{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Watabe T"],"funding":["Japan Science and Technology Agency"],"pagination":["9434"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9409053"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(16)"],"pubmed_abstract":["Astatine (<sup>211</sup>At) is an alpha-emitter with a better treatment efficacy against differentiated thyroid cancer compared with iodine (<sup>131</sup>I), a conventional beta-emitter. However, its therapeutic comparison has not been fully evaluated. In this study, we compared the therapeutic effect between [<sup>211</sup>At]NaAt and [<sup>131</sup>I]NaI. In vitro analysis of a double-stranded DNA break (DSB) and colony formation assay were performed using K1-NIS cells. The therapeutic effect was compared using K1-NIS xenograft mice administered with [<sup>211</sup>At]NaAt (0.4 MBq (n = 7), 0.8 MBq (n = 9), and 1.2 MBq (n = 4)), and [<sup>131</sup>I]NaI (1 MBq (n = 4), 3 MBq (n = 4), and 8 MBq (n = 4)). The [<sup>211</sup>At]NaAt induced higher numbers of DSBs and had a more reduced col"],"journal":["International journal of molecular sciences"],"pubmed_title":["Comparison of the Therapeutic Effects of [<sup>211</sup>At]NaAt and [<sup>131</sup>I]NaI in an NIS-Expressing Thyroid Cancer Mouse Model."],"pmcid":["PMC9409053"],"funding_grant_id":["JPMJOP1721"],"pubmed_authors":["Haba H","Shimosegawa E","Toyoshima A","Nakano T","Kaneda-Nakashima K","Liu Y","Sato T","Watabe T","Shinohara A","Hatazawa J","Wang Y","Ooe K","Shirakami Y"],"additional_accession":[]},"is_claimable":false,"name":"Comparison of the Therapeutic Effects of [<sup>211</sup>At]NaAt and [<sup>131</sup>I]NaI in an NIS-Expressing Thyroid Cancer Mouse Model.","description":"Astatine (<sup>211</sup>At) is an alpha-emitter with a better treatment efficacy against differentiated thyroid cancer compared with iodine (<sup>131</sup>I), a conventional beta-emitter. However, its therapeutic comparison has not been fully evaluated. In this study, we compared the therapeutic effect between [<sup>211</sup>At]NaAt and [<sup>131</sup>I]NaI. In vitro analysis of a double-stranded DNA break (DSB) and colony formation assay were performed using K1-NIS cells. The therapeutic effect was compared using K1-NIS xenograft mice administered with [<sup>211</sup>At]NaAt (0.4 MBq (n = 7), 0.8 MBq (n = 9), and 1.2 MBq (n = 4)), and [<sup>131</sup>I]NaI (1 MBq (n = 4), 3 MBq (n = 4), and 8 MBq (n = 4)). The [<sup>211</sup>At]NaAt induced higher numbers of DSBs and had a more reduced col","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Aug","modification":"2025-04-27T02:29:39.503Z","creation":"2025-02-19T04:38:09.94Z"},"accession":"S-EPMC9409053","cross_references":{"pubmed":["36012698"],"doi":["10.3390/ijms23169434"]}}